Oncogenic mechanisms in renal insufficiency.
Clin Kidney J
; 14(2): 507-515, 2021 Feb.
Article
en En
| MEDLINE
| ID: mdl-33623673
The prevalence of both cancer and end-stage renal disease is increasing. In addition, medical advances have meant increased survival rates for both diseases. Many chemotherapeutics are renally excreted, and conversely, renal insufficiency promotes a pro-neoplastic state, including genitourinary and other cancers. Dialysis prolongs life while increasing cancer risk. Proposed oncogenic mechanisms include immune dysfunction, chronic inflammation, changes in gut microbiota and stimulation of the renin-angiotensin system. This review summarizes current concepts in the relationship between cancer and renal insufficiency.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Tipo de estudio:
Risk_factors_studies
Idioma:
En
Revista:
Clin Kidney J
Año:
2021
Tipo del documento:
Article
País de afiliación:
Rumanía
Pais de publicación:
Reino Unido