Tetanus and tetanus neurotoxin: From peripheral uptake to central nervous tissue targets.
J Neurochem
; 158(6): 1244-1253, 2021 09.
Article
en En
| MEDLINE
| ID: mdl-33629408
ABSTRACT
Tetanus is a deadly but preventable disease caused by a protein neurotoxin produced by Clostridium tetani. Spores of C. tetani may contaminate a necrotic wound and germinate into a vegetative bacterium that releases a toxin, termed tetanus neurotoxin (TeNT). TeNT enters the general circulation, binds to peripheral motor neurons and sensory neurons, and is transported retroaxonally to the spinal cord. It then enters inhibitory interneurons and blocks the release of glycine or GABA causing a spastic paralysis. This review attempts to correlate the metalloprotease activity of TeNT and its trafficking and localization into the vertebrate body to the nature and sequence of appearance of the symptoms of tetanus.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Nervios Periféricos
/
Médula Espinal
/
Tétanos
/
Toxina Tetánica
/
Encéfalo
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Neurochem
Año:
2021
Tipo del documento:
Article
País de afiliación:
Italia