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Gelatin-loaded cubosomes stabilized with hydrophobically modified quaternized cellulose nanofiber and their pH-dependent release property.
Park, Seok Ho; Zhao, Fanyu; Park, Soo Chan; Kim, Jin-Chul.
Afiliación
  • Park SH; Department of Biomedical Science & Institute of Bioscience and Biotechnology, Kangwon National University, Chuncheon, Republic of Korea These authors contributed equally to this study.
  • Zhao F; Department of Biomedical Science & Institute of Bioscience and Biotechnology, Kangwon National University, Chuncheon, Republic of Korea These authors contributed equally to this study.
J Biomater Appl ; 35(9): 1109-1118, 2021 04.
Article en En | MEDLINE | ID: mdl-33632005
Monoolein cubic phase immobilizing hydrophobically modified gelatin (HmGel) in its water channel was prepared by a melt-hydration method. The cubic phase was micronized into cubosomes by using hydrophobically modified quaternized cellulose nanofiber (HmQCNF) as a stabilizer. The phase transition temperature of the cubic phase was about 68-70 °C. Small angle X-ray diffraction revealed that HmGel-loaded cubosome stabilized with HmCNF was a diamond type of cubic phase. HmGel-loaded cubosomes stailized with HmQCNF were dependent on the pH value in terms of the release of their payload (i.e, methylene blue) much more strongly than HmGel-loaded cubosomes stabilized with Pluronic F127.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Colorantes / Nanofibras / Gelatina Idioma: En Revista: J Biomater Appl Asunto de la revista: ENGENHARIA BIOMEDICA Año: 2021 Tipo del documento: Article Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Colorantes / Nanofibras / Gelatina Idioma: En Revista: J Biomater Appl Asunto de la revista: ENGENHARIA BIOMEDICA Año: 2021 Tipo del documento: Article Pais de publicación: Reino Unido