Acute Dose-Dependent Neuroprotective Effects of Poly(pro-17ß-estradiol) in a Mouse Model of Spinal Contusion Injury.
ACS Chem Neurosci
; 12(6): 959-965, 2021 03 17.
Article
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| MEDLINE
| ID: mdl-33635633
ABSTRACT
17ß-Estradiol (E2) confers neuroprotection in preclinical models of spinal cord injury when administered systemically. The goal of this study was to apply E2 locally to the injured spinal cord for a sustained duration using poly(pro-E2) film biomaterials. Following contusive spinal cord injury in adult male mice, poly(pro-E2) films were implanted subdurally and neuroprotection was assessed using immunohistochemistry 7 days after injury and implantation. In these studies, poly(pro-E2) films modestly improved neuroprotection without affecting the inflammatory response when compared to the injured controls. To increase the E2 dose released, bolus-releasing poly(pro-E2) films were fabricated by incorporating unbound E2 into the poly(pro-E2) films. However, compared to the injured controls, bolus-releasing poly(pro-E2) films did not significantly enhance neuroprotection or limit inflammation at either 7 or 21 days post-injury. Future work will focus on developing poly(pro-E2) biomaterials capable of more precisely releasing therapeutic doses of E2.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Traumatismos de la Médula Espinal
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Fármacos Neuroprotectores
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Contusiones
Límite:
Animals
Idioma:
En
Revista:
ACS Chem Neurosci
Año:
2021
Tipo del documento:
Article
País de afiliación:
Estados Unidos