The Multifaceted Roles of KCC2 in Cortical Development.
Trends Neurosci
; 44(5): 378-392, 2021 05.
Article
en En
| MEDLINE
| ID: mdl-33640193
ABSTRACT
KCC2, best known as the neuron-specific chloride-extruder that sets the strength and polarity of GABAergic currents during neuronal maturation, is a multifunctional molecule that can regulate cytoskeletal dynamics via its C-terminal domain (CTD). We describe the molecular and cellular mechanisms involved in the multiple functions of KCC2 and its splice variants, ranging from developmental apoptosis and the control of early network events to the formation and plasticity of cortical dendritic spines. The versatility of KCC2 actions at the cellular and subcellular levels is also evident in mature neurons during plasticity, disease, and aging. Thus, KCC2 has emerged as one of the most important molecules that shape the overall neuronal phenotype.
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Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Simportadores
Límite:
Humans
Idioma:
En
Revista:
Trends Neurosci
Año:
2021
Tipo del documento:
Article
País de afiliación:
Finlandia