AIRE, autoimmune regulator; AKT, AKT serine/threonine kinase; ATR, ataxia telangiectasia-mutated and Rad3-related; BCL2, BCL2 apoptosis regulator; BMAL1, aryl hydrocarbon receptor nuclear translocator like; CDK2/4, cyclin dependent kinase 2/4; CDT2, denticleless E3 ubiquitin protein ligase homolog; CHK1, checkpoint kinase 1; CK1/2, casein kinase I/II; CLOCK, clock circadian regulator; COMMD1, copper metabolism domain containing 1; CRL, cullin-RING ligase; CRY1, cryptochrome circadian regulator 1; CSN, COP9 signalosome; Ci, cubitus interruptus; Crosstalk; Cullin-RING ligases; DDB1, damage specific DNA binding protein 1; DYRK1A/B, dual-specificity tyrosine-phosphorylation-regulated kinases 1A/B; Degradation; EMT, epithelial­mesenchymal transition; ERG, ETS transcription factor ERG; ERK, mitogen-activated protein kinase 1; EXO1, exonuclease 1; FBW7, F-box and WD repeat domain containing 7; FBXL3, F-box and leucine rich repeat protein; FBXO3/31, F-box protein 3/31; FZR1, fizzy and cell division cycle 20 related 1; HCC, hepatocellular carcinomas; HIB, Hedghog-induced MATH and BTB domain-containing protein; HIF1α, NF-κB and hypoxia inducible factor 1 subunit alpha; ID2, inhibitor of DNA binding 2; JAB1, c-Jun activation domain binding protein-1; KBTBD8, kelch repeat and BTB domain containing 8; KDM2B, lysine demethylase 2B; KEAP1, kelch like ECH associated protein 1; KLHL3, kelch like family member 3; KRAS, KRAS proto-oncogene, GTPase; Kinases; MYC, MYC proto-oncogene, bHLH transcription factor; NEDD8, NEDD8 ubiquitin like modifier; NOLC1, nucleolar and coiled-body phosphoprotein 1; NRF2, nuclear factor, erythroid 2 like 2; P-TEFb, positive transcription elongation factor b; PDL1, programmed death ligand 1; PKC, protein kinase C; PKM2, pyruvate kinase M2 isoform; PYGO2, pygopus 2; Phosphorylation; RA, retinoic acid; RARα, RA receptor α; RRM2, ribonucleotide reductase regulatory subunit M2; SNAIL1, snail family transcriptional repressor 1; SOCS6, suppressor of cytokine signaling 6; SPOP, speckle-type POZ protein; SRC-3, nuclear receptor coactivator 3; TCN, triciribine hydrate; TCOF1, treacle ribosome biogenesis factor 1; TRF1, telomeric repeat binding factor 1; Targeted therapy; Tumorigenesis; USP37, ubiquitin specific peptidase 37; Ubiquitination; VHL, von Hippel-Lindau tumor suppressor; Vps34, phosphatidylinositol 3-kinase catalytic subunit type 3; XBP1, X-box binding protein 1; ZBTB16, zinc finger and BTB domain containing 16; c-Fos, Fos proto-oncogene, AP-1 transcription factor subunit; p130Cas, BCAR1 scaffold protein, Cas family member