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Gastric mucosal changes, and sex differences therein, after Helicobacter pylori eradication: A long-term prospective follow-up study.
Kodama, Masaaki; Okimoto, Tadayoshi; Mizukami, Kazuhiro; Hirashita, Yuka; Wada, Yasuhiro; Fukuda, Masahide; Matsunari, Osamu; Okamoto, Kazuhisa; Ogawa, Ryo; Fukuda, Kensuke; Kudo, Yoko; Kawahara, Yoshinari; Murakami, Kazunari.
Afiliación
  • Kodama M; Department of Gastroenterology, Faculty of Medicine, Oita University, Yufu, Japan.
  • Okimoto T; Faculty of Welfare and Health Science, Oita University, Oita, Japan.
  • Mizukami K; Department of Gastroenterology, Faculty of Medicine, Oita University, Yufu, Japan.
  • Hirashita Y; Department of Gastroenterology, Faculty of Medicine, Oita University, Yufu, Japan.
  • Wada Y; Department of Gastroenterology, Faculty of Medicine, Oita University, Yufu, Japan.
  • Fukuda M; Department of Gastroenterology, Faculty of Medicine, Oita University, Yufu, Japan.
  • Matsunari O; Department of Gastroenterology, Faculty of Medicine, Oita University, Yufu, Japan.
  • Okamoto K; Department of Gastroenterology, Faculty of Medicine, Oita University, Yufu, Japan.
  • Ogawa R; Department of Gastroenterology, Faculty of Medicine, Oita University, Yufu, Japan.
  • Fukuda K; Department of Gastroenterology, Faculty of Medicine, Oita University, Yufu, Japan.
  • Kudo Y; Department of Gastroenterology, Faculty of Medicine, Oita University, Yufu, Japan.
  • Kawahara Y; Department of Gastroenterology, Faculty of Medicine, Oita University, Yufu, Japan.
  • Murakami K; Department of Gastroenterology, Faculty of Medicine, Oita University, Yufu, Japan.
J Gastroenterol Hepatol ; 36(8): 2210-2216, 2021 Aug.
Article en En | MEDLINE | ID: mdl-33656793
BACKGROUND AND AIM: Improvement of atrophic gastritis and intestinal metaplasia (IM) is considered to reduce the gastric cancer risk, but whether it can be achieved by H. pylori eradication (HPE) remains controversial. To evaluate the effect of HPE, we observed the gastric mucosa for up to17 years after HPE and sex differences in gastric mucosa. METHODS: In total, 172 patients (94 males, 78 females) with HPE were enrolled. Annual histological evaluations were performed for up to 17 years. The grades of mononuclear cells, neutrophils, atrophy, IM in the antrum and corpus were evaluated using the updated Sydney system. RESULTS: Relative to the pre-HPE period, atrophy had improved significantly 1 year after HPE in the antrum (1.50 ± 0.75 vs. 1.21 ± 1.25, P < 0.01) and corpus (0.59 ± 0.75 vs. 0.18 ± 0.52, P < 0.05). IM showed no significant change during 17 years after HPE at either biopsy site. Atrophy scores did not differ significantly between males and females. IM scores were significantly higher in males than in females before eradication (antrum, 0.67 ± 0.94 vs. 0.44 ± 0.77, P = 0.003, corpus, 0.20 ± 0.62 vs. 0.047 ± 0.21, P = 0.0027) and at most observation timepoints. CONCLUSIONS: During 17 years after HPE, atrophy, but not IM, improved significantly at the greater curvatures of the antrum and corpus. IM was significantly more severe in males than in females. Careful follow-up after HPE based on sex differences in gastric mucosal characteristics is important.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Helicobacter pylori / Infecciones por Helicobacter / Inhibidores de la Bomba de Protones / Mucosa Gástrica / Antibacterianos Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Gastroenterol Hepatol Asunto de la revista: GASTROENTEROLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Australia

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Helicobacter pylori / Infecciones por Helicobacter / Inhibidores de la Bomba de Protones / Mucosa Gástrica / Antibacterianos Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Gastroenterol Hepatol Asunto de la revista: GASTROENTEROLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Australia