Total Synthesis of Ritterazine B.
J Am Chem Soc
; 143(11): 4187-4192, 2021 03 24.
Article
en En
| MEDLINE
| ID: mdl-33689345
The first total synthesis of the cytotoxic alkaloid ritterazine B is reported. The synthesis features a unified approach to both steroid subunits, employing a titanium-mediated propargylation reaction to achieve divergence from a common precursor. Other key steps include gold-catalyzed cycloisomerizations that install both spiroketals and late stage C-H oxidation to incorporate the C7' alcohol.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fenazinas
/
Compuestos de Espiro
/
Esteroides
/
Antineoplásicos
Límite:
Animals
Idioma:
En
Revista:
J Am Chem Soc
Año:
2021
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
Estados Unidos