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Preoperative weight loss in women with obesity in gynaecologic oncology: A retrospective study.
Aubrey, Christa; Skeldon, Matthew; Chapelsky, Sarah; Giannakopoulos, Nadia; Ghosh, Sunita; Steed, Helen; Pin, Sophia.
Afiliación
  • Aubrey C; Gynecologic Oncology Fellow, Tom Baker Cancer Centre, Department of Oncology, University of Calgary, Calgary, Alberta, Canada.
  • Skeldon M; Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.
  • Chapelsky S; Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.
  • Giannakopoulos N; Department of Anatomic Pathology, University of Alberta, Edmonton, Alberta, Canada.
  • Ghosh S; Research Scientist, Alberta Health Services-Cancer Control Alberta, Department of Medical Oncology, University of Alberta, Edmonton, Alberta, Canada.
  • Steed H; Cross Cancer Institute, Department of Obstetrics and Gynecology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.
  • Pin S; Cross Cancer Institute, Department of Obstetrics and Gynecology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.
Clin Obes ; 11(3): e12445, 2021 Jun.
Article en En | MEDLINE | ID: mdl-33710796
ABSTRACT
To retrospectively review the efficacy of short term supervised medical weight loss for women with obesity, body mass index (BMI ≥40 kg/m2 ) in gynaecologic oncology, and the associated perioperative and pathologic outcomes. A retrospective study of a dedicated preoperative weight loss clinic for gynaecologic oncology patients from March to December 2019. Statistical analysis was performed with McNemar's test for correlated proportions, Pearson's correlation tests for continuous variables, and paired t-tests to compare means. Generalized estimating equations (GEE) were used to determine the factors associated with weight loss over time. A P-value of <.05 was used for statistical significance. Review of cases up-graded after surgery was performed by a gynaecologic pathologist. There were a total of 49 women included in the study. The most common referral reason was endometrioid carcinoma or hyperplasia of the endometrium (77.6%). Mean initial weight was 130.2 kg, and corresponding mean BMI 48.1 kg/m2 . Patients attended on average nine preoperative weight loss visits. A significant difference between initial weight and weight at surgery was demonstrated, from 129.6 to 118.0 kg (8.4% weight loss) (P < .0001). This difference persisted to their post-surgical visit, with an additional mean loss of 1.89 kg (9.4% weight loss) (P = .044). The majority (92.1%) of patients with endometrial pathology had surgical management, and of these 85.7% were minimally invasive. Preoperative weight loss is a feasible option in gynaecologic oncology patients. Greater understanding of clinical significance, follow-up, and ideal target population for this intervention is needed.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pérdida de Peso / Neoplasias de los Genitales Femeninos Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Female / Humans Idioma: En Revista: Clin Obes Año: 2021 Tipo del documento: Article País de afiliación: Canadá

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pérdida de Peso / Neoplasias de los Genitales Femeninos Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Female / Humans Idioma: En Revista: Clin Obes Año: 2021 Tipo del documento: Article País de afiliación: Canadá