[Effects of Obstetric Analgesia with Systemic Opioids on the Newborn - A Review]. / Auswirkungen geburtshilflicher Analgesie mit systemischen Opioiden auf das Neugeborene eine Übersichtsarbeit.
Z Geburtshilfe Neonatol
; 225(6): 473-483, 2021 12.
Article
en De
| MEDLINE
| ID: mdl-33752247
ABSTRACT
INTRODUCTION:
Three-quarters of all women receive analgesia during labor. There are regional and systemic analgesia procedures available. In this review, we investigate the impact of obstetric analgesia using systemic opioids on neonatal outcomes.METHODS:
We searched the PubMed and Cochrane Library databases using the following search terms "meptazinol", "meptide", "analgesia", "painkiller", "pain reliever", "obstetrics", "labor", "labour", "delivery", "neonate", "newborn", "child", "baby", "infant", "fetus", "fetal", "opioid" and "opiate" as well as performed an additional MeSH Terms search in PubMed.RESULTS:
Of 355 potentially relevant studies, we included 23 studies in this review. The studies varied widely in quality, sample size, and outcome criteria. Neonatal outcome was often only a secondary endpoint. Rarely were significant differences related to neonatal outcome reported between the different systemic opioids or compared with control groups. Twelve studies compared neonatal APGAR scores between treatment groups, with ten (83%) of these studies showing no differences. DISCUSSION/OUTLOOK In summary, we assess the evidence as limited and ambiguous as to whether systemic obstetric opioid therapy negatively affects the newborn. Studies regarding the long-term outcome of the newborns are lacking. A statement regarding the necessity of postnatal monitoring of newborns after maternal obstetric opioid therapy cannot be concluded. Further studies, ideally with a prospective study design and control group, should be considered.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Trabajo de Parto
/
Analgesia Obstétrica
Tipo de estudio:
Observational_studies
/
Systematic_reviews
Límite:
Female
/
Humans
/
Newborn
/
Pregnancy
Idioma:
De
Revista:
Z Geburtshilfe Neonatol
Asunto de la revista:
PERINATOLOGIA
Año:
2021
Tipo del documento:
Article