Salivary irisin: potential inflammatory biomarker in recurrent apthous stomatitis patients.
Eur Rev Med Pharmacol Sci
; 25(5): 2252-2259, 2021 03.
Article
en En
| MEDLINE
| ID: mdl-33755963
ABSTRACT
OBJECTIVE:
Recurrent Aphthous Stomatitis (RAS) is the most common inflammatory condition of the oral mucosa characterised by recurrent onset of single or multiple painful ulcers mainly affecting the nonkeratinized oral mucosa. RAS mostly occurs in healthy individuals with no associated systemic diseases. Irisin is a newly identified adipomyokine and research has revealed that it has anti-inflammatory effects. The aim of this study was to investigate the significance of salivary irisin levels in patients with recurrent apthous stomatitis (RAS). PATIENTS ANDMETHODS:
In this investigation, 80 individuals were evaluated. The patient group included 30 patients diagnosed with RAS and each control group consisted of 25 smoker and non-smoker healthy individuals. Saliva samples were collected and salivary irisin, interleukin-2 (IL-2) and interferon-É£ (IF-É£) levels were determined using enzyme-linked immunosorbent assay (ELISA).RESULTS:
IL-2 and IF-É£ levels in RAS patients were significantly higher than control smoker and non-smoker groups (p=0.0001, p=0.0001, respectively). Irisin level was higher in RAS patients than smoker controls and non-smoker controls. The level of irisin was found as sensitive and specific as IL-2 and more sensitive and specific than IF-É£. The salivary levels of pro-inflammatory cytokines IL-2 and IF-É£ and irisin were higher in RAS group compared to controls.CONCLUSIONS:
This is the first report evaluating the irisin an adipo-myokine as an inflammatory biomarker in RAS.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Saliva
/
Estomatitis Aftosa
/
Fibronectinas
Tipo de estudio:
Prognostic_studies
Límite:
Adult
/
Humans
Idioma:
En
Revista:
Eur Rev Med Pharmacol Sci
Asunto de la revista:
FARMACOLOGIA
/
TOXICOLOGIA
Año:
2021
Tipo del documento:
Article
País de afiliación:
Turquía