Suckling by Schistosoma mansoni-infected mothers restored IgG2a and TGF-ß production, but not IL-6 and delayed-type hypersensitivity in IL-12/IL-23-deficient mice.
Rev Soc Bras Med Trop
; 54: e0744-2020, 2021.
Article
en En
| MEDLINE
| ID: mdl-33759926
ABSTRACT
INTRODUCTION:
Suckling by schistosomotic mice improves anti-ovalbumin (OA) antibody production, while delayed-type hypersensitivity (DTH) remains unaffected. This property of milk from schistosomotic mice was investigated in IL-12/IL-23-deficient mice (IL-12p40KO).METHODS:
We compared anti-OA DTH, IgG2a and cytokines in wild-type and IL-12p40KO mice suckled by infected (SIM) or non-infected (CONTROL) mothers.RESULTS:
SIM mice showed similar intensity and eosinophils in the DTH, which was abolished in IL-12p40KO and IL-12p40KO-SIM mice. In IL-12p40KO-SIM, IgG2a and TGF-ß levels were higher, but IL-6 levels were lower.CONCLUSIONS:
Milk from schistosomotic mothers may evoke IgG2a without eliciting DTH in IL-12/IL-23 deficiencies, by changing TGF-ß/IL-6 levels.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Schistosoma mansoni
/
Interleucina-12
Límite:
Animals
/
Female
/
Humans
Idioma:
En
Revista:
Rev Soc Bras Med Trop
Año:
2021
Tipo del documento:
Article
País de afiliación:
Brasil