Effect of Memantine Treatment and Combination with Vitamin D Supplementation on Body Composition in the APP/PS1 Mouse Model of Alzheimer's Disease Following Chronic Vitamin D Deficiency.
J Alzheimers Dis
; 81(1): 375-388, 2021.
Article
en En
| MEDLINE
| ID: mdl-33780366
ABSTRACT
BACKGROUND:
Vitamin D deficiency and altered body composition are common in Alzheimer's disease (AD). Memantine with vitamin D supplementation can protect cortical axons against amyloid-ß exposure and glutamate toxicity.OBJECTIVE:
To study the effects of vitamin D deprivation and subsequent treatment with memantine and vitamin D enrichment on whole-body composition using a mouse model of AD.METHODS:
Male APPswe/PS1dE9 mice were divided into four groups at 2.5 months of age the control group (nâ=â14) was fed a standard diet throughout; the remaining mice were started on a vitamin D-deficient diet at month 6. The vitamin D-deficient group (nâ=â14) remained on the vitamin D-deficient diet for the rest of the study. Of the remaining two groups, one had memantine (nâ=â14), while the other had both memantine and 10 IU/g vitamin D (nâ=â14), added to their diet at month 9. Serum 25(OH)D levels measured at months 6, 9, 12, and 15 confirmed vitamin D levels were lower in mice on vitamin D-deficient diets and higher in the vitamin D-supplemented mice. Micro-computed tomography was performed at month 15 to determine whole-body composition.RESULTS:
In mice deprived of vitamin D, memantine increased bone mineral content (8.7% increase, pâ<â0.01) and absolute skeletal tissue mass (9.3% increase, pâ<â0.05) and volume (9.2% increase, pâ<â0.05) relative to controls. This was not observed when memantine treatment was combined with vitamin D enrichment.CONCLUSION:
Combination treatment of vitamin D and memantine had no negative effects on body composition. Future studies should clarify whether vitamin D status impacts the effects of memantine treatment on bone physiology in people with AD.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Vitamina D
/
Deficiencia de Vitamina D
/
Composición Corporal
/
Dopaminérgicos
/
Memantina
/
Enfermedad de Alzheimer
Límite:
Animals
Idioma:
En
Revista:
J Alzheimers Dis
Asunto de la revista:
GERIATRIA
/
NEUROLOGIA
Año:
2021
Tipo del documento:
Article
País de afiliación:
Canadá
Pais de publicación:
HOLANDA
/
HOLLAND
/
NETHERLANDS
/
NL
/
PAISES BAJOS
/
THE NETHERLANDS