The folate cycle enzyme MTHFD2 induces cancer immune evasion through PD-L1 up-regulation.

Shang, Man; Yang, Huijie; Yang, Ran; Chen, Tao; Fu, Yuan; Li, Yeyi; Fang, Xianlong; Zhang, Kangjian; Zhang, Jianju; Li, Hui; Cao, Xueping; Gu, Jinfa; Xiao, Jianwen; Zhang, Qi; Liu, Xinyuan; Yu, Qiujing; Wang, Ting

Shang, Man; Yang, Huijie; Yang, Ran; Chen, Tao; Fu, Yuan; Li, Yeyi; Fang, Xianlong; Zhang, Kangjian; Zhang, Jianju; Li, Hui; Cao, Xueping; Gu, Jinfa; Xiao, Jianwen; Zhang, Qi; Liu, Xinyuan; Yu, Qiujing; Wang, Ting.

Afiliación

Shang M; Department of Pharmacology, Tianjin Key Laboratory of Inflammatory Biology, The province and ministry co-sponsored collaborative innovation center for medical epigenetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
Yang H; Department of Pharmacology, Tianjin Key Laboratory of Inflammatory Biology, The province and ministry co-sponsored collaborative innovation center for medical epigenetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
Yang R; Department of Pharmacology, Tianjin Key Laboratory of Inflammatory Biology, The province and ministry co-sponsored collaborative innovation center for medical epigenetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
Chen T; Endoscopy Center, Shanghai East Hospital, Tongji University, Shanghai, China.
Fu Y; Department of Pharmacology, Tianjin Key Laboratory of Inflammatory Biology, The province and ministry co-sponsored collaborative innovation center for medical epigenetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
Li Y; Department of Pharmacology, Tianjin Key Laboratory of Inflammatory Biology, The province and ministry co-sponsored collaborative innovation center for medical epigenetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
Fang X; Shanghai Yuansong Bio-technology Limited Company, Shanghai, China.
Zhang K; Shanghai Yuansong Bio-technology Limited Company, Shanghai, China.
Zhang J; State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Beijing, China.
Li H; Department of Pediatric Surgery, Tianjin Medical University General Hospital, Tianjin, China.
Cao X; Shanghai Yuansong Bio-technology Limited Company, Shanghai, China.
Gu J; Shanghai Yuansong Bio-technology Limited Company, Shanghai, China.
Xiao J; Shanghai Yuansong Bio-technology Limited Company, Shanghai, China.
Zhang Q; State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Beijing, China.
Liu X; Shanghai Yuansong Bio-technology Limited Company, Shanghai, China.
Yu Q; Tianjin Key Laboratory of Acute Abdomen Disease Associated Organ Injury and ITCWM Repair, Institute of Integrative Medicine for Acute Abdominal Diseases, Integrated Chinese and Western Medicine Hospital (Nankai Hospital), Tianjin University, Tianjin, China.
Wang T; State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Beijing, China.

Nat Commun ; 12(1): 1940, 2021 03 29.

Article en En | MEDLINE | ID: mdl-33782411

Asunto(s)

Aminohidrolasas/genética; Antígeno B7-H1/genética; Carcinogénesis/genética; Regulación Neoplásica de la Expresión Génica; Metilenotetrahidrofolato Deshidrogenasa (NADP)/genética; Enzimas Multifuncionales/genética; Neoplasias Pancreáticas/genética; Procesamiento Proteico-Postraduccional; Linfocitos T Citotóxicos/inmunología; Aminohidrolasas/antagonistas & inhibidores; Aminohidrolasas/inmunología; Animales; Antígeno B7-H1/antagonistas & inhibidores; Antígeno B7-H1/inmunología; Carcinogénesis/inmunología; Carcinogénesis/patología; Línea Celular Tumoral; Embrión de Mamíferos; Fibroblastos/inmunología; Fibroblastos/patología; Ácido Fólico/inmunología; Ácido Fólico/metabolismo; Humanos; Masculino; Diana Mecanicista del Complejo 1 de la Rapamicina/genética; Diana Mecanicista del Complejo 1 de la Rapamicina/inmunología; Metilenotetrahidrofolato Deshidrogenasa (NADP)/antagonistas & inhibidores; Metilenotetrahidrofolato Deshidrogenasa (NADP)/inmunología; Ratones; Ratones Endogámicos BALB C; Ratones Endogámicos C57BL; Ratones Desnudos; Enzimas Multifuncionales/antagonistas & inhibidores; Enzimas Multifuncionales/inmunología; Neoplasias Pancreáticas/inmunología; Neoplasias Pancreáticas/patología; Cultivo Primario de Células; Proteínas Proto-Oncogénicas c-akt/genética; Proteínas Proto-Oncogénicas c-akt/inmunología; Proteínas Proto-Oncogénicas c-myc/antagonistas & inhibidores; Proteínas Proto-Oncogénicas c-myc/genética; Proteínas Proto-Oncogénicas c-myc/inmunología; ARN Interferente Pequeño/genética; ARN Interferente Pequeño/inmunología; Transducción de Señal; Linfocitos T Citotóxicos/patología; Carga Tumoral; Escape del Tumor; Uridina Difosfato N-Acetilglucosamina/metabolismo; Ensayos Antitumor por Modelo de Xenoinjerto

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Linfocitos T Citotóxicos / Regulación Neoplásica de la Expresión Génica / Procesamiento Proteico-Postraduccional / Antígeno B7-H1 / Carcinogénesis / Enzimas Multifuncionales / Aminohidrolasas / Metilenotetrahidrofolato Deshidrogenasa (NADP) Tipo de estudio: Prognostic_studies Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google