Air distribution within the lungs after total liquid ventilation in a neonatal ovine model.
Respir Physiol Neurobiol
; 290: 103666, 2021 08.
Article
en En
| MEDLINE
| ID: mdl-33798788
ABSTRACT
OBJECTIVE:
To gain insight into the total and regional lung aeration dynamics at the transition from total liquid ventilation (TLV) to conventional mechanical ventilation (GV).METHODS:
Neonatal lambs received either TLV for 4 h followed by GV (n = 15) or GV only (n = 11, controls). Monitoring was performed in the prone position with both videofluoroscopy and electrical impedance tomography (EIT) for the first 10 min of the transition.RESULTS:
Total and regional end-expiratory lung volumes were stable throughout the transition (p < 0.05). The percentage of tidal volume, liquid and/or gaseous, distributed to the different regions was stable (p < 0.05). Radiopacity of the nondependent regions markedly decreased at end-expiration (p < 0.01), reflecting the progressive transition to a gaseous end-expiratory lung volume.CONCLUSION:
Weaning to GV did not increase total or regional lung volumes, suggesting that the risk of overdistention was not increased. Residual perfluorocarbon in the dependent lung regions might account for the high O2 needs we observed in the first minutes of GV after TLV.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Desconexión del Ventilador
/
Ventilación Liquida
/
Enfermedades del Prematuro
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Enfermedades Pulmonares
Límite:
Animals
Idioma:
En
Revista:
Respir Physiol Neurobiol
Año:
2021
Tipo del documento:
Article