Molecular Docking and Biophysical Studies for Antiproliferative Assessment of Synthetic Pyrazolo-Pyrimidinones Tethered with Hydrazide-Hydrazones.

Horchani, Mabrouk; Della Sala, Gerardo; Caso, Alessia; D'Aria, Federica; Esposito, Germana; Laurenzana, Ilaria; Giancola, Concetta; Costantino, Valeria; Jannet, Hichem Ben; Romdhane, Anis

Horchani, Mabrouk; Della Sala, Gerardo; Caso, Alessia; D'Aria, Federica; Esposito, Germana; Laurenzana, Ilaria; Giancola, Concetta; Costantino, Valeria; Jannet, Hichem Ben; Romdhane, Anis.

Afiliación

Horchani M; Laboratory of Heterocyclic Chemistry, Natural Products and Reactivity, Medicinal Chemistry and Natural Products (LR11ES39), Faculty of Sciences of Monastir, University of Monastir, 5000 Monastir, Tunisia.
Della Sala G; Department of Marine Biotechnology, Stazione Zoologica Anton Dohrn, Villa Comunale, 80125 Naples, Italy.
Caso A; Laboratory of Pre-Clinical and Translational Research, IRCCS-CROB, Referral Cancer Center of Basilicata, 85028 Rionero in Vulture, Italy.
D'Aria F; The Blue Chemistry Lab, Department of Pharmacy, University of Naples Federico II, Via D. Montesano 49, 80131 Naples, Italy.
Esposito G; Department of Pharmacy, University of Naples Federico II, Via D. Montesano 49, 80131 Naples, Italy.
Laurenzana I; The Blue Chemistry Lab, Department of Pharmacy, University of Naples Federico II, Via D. Montesano 49, 80131 Naples, Italy.
Giancola C; Laboratory of Pre-Clinical and Translational Research, IRCCS-CROB, Referral Cancer Center of Basilicata, 85028 Rionero in Vulture, Italy.
Costantino V; Department of Pharmacy, University of Naples Federico II, Via D. Montesano 49, 80131 Naples, Italy.
Jannet HB; The Blue Chemistry Lab, Department of Pharmacy, University of Naples Federico II, Via D. Montesano 49, 80131 Naples, Italy.
Romdhane A; Laboratory of Heterocyclic Chemistry, Natural Products and Reactivity, Medicinal Chemistry and Natural Products (LR11ES39), Faculty of Sciences of Monastir, University of Monastir, 5000 Monastir, Tunisia.

Int J Mol Sci ; 22(5)2021 Mar 08.

Article en En | MEDLINE | ID: mdl-33800505

Asunto(s)

Apoptosis/efectos de los fármacos; Neoplasias de la Mama; Proliferación Celular/efectos de los fármacos; G-Cuádruplex; Simulación del Acoplamiento Molecular; Proteínas Proto-Oncogénicas p21(ras); Pirimidinonas; Antineoplásicos; Neoplasias de la Mama/tratamiento farmacológico; Neoplasias de la Mama/metabolismo; Neoplasias de la Mama/patología; Ensayos de Selección de Medicamentos Antitumorales; Receptores ErbB/antagonistas & inhibidores; Receptores ErbB/química; Receptores ErbB/metabolismo; Femenino; Humanos; Células MCF-7; Proteínas Proto-Oncogénicas p21(ras)/antagonistas & inhibidores; Proteínas Proto-Oncogénicas p21(ras)/química; Proteínas Proto-Oncogénicas p21(ras)/metabolismo; Pirimidinonas/síntesis química; Pirimidinonas/química; Pirimidinonas/farmacología

Palabras clave

G-quadruplex DNA; KRAS; antiproliferative activity; antitumor lead compound; circular dichroism; cytotoxic activity; epidermal growth factor receptor; hydrazide-hydrazone; molecular docking; pyrazolopyrimidinone

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pirimidinonas / Neoplasias de la Mama / Proteínas Proto-Oncogénicas p21(ras) / Apoptosis / Proliferación Celular / G-Cuádruplex / Simulación del Acoplamiento Molecular Límite: Female / Humans Idioma: En Revista: Int J Mol Sci Año: 2021 Tipo del documento: Article País de afiliación: Túnez Pais de publicación: Suiza

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