Actin-Resistant DNase1L2 as a Potential Therapeutics for CF Lung Disease.

Delfino, Danila; Mori, Giulia; Rivetti, Claudio; Grigoletto, Antonella; Bizzotto, Gloria; Cavozzi, Cristian; Malatesta, Marco; Cavazzini, Davide; Pasut, Gianfranco; Percudani, Riccardo

Delfino, Danila; Mori, Giulia; Rivetti, Claudio; Grigoletto, Antonella; Bizzotto, Gloria; Cavozzi, Cristian; Malatesta, Marco; Cavazzini, Davide; Pasut, Gianfranco; Percudani, Riccardo.

Afiliación

Delfino D; Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, 43124 Parma, Italy.
Mori G; Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, 43124 Parma, Italy.
Rivetti C; Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, 43124 Parma, Italy.
Grigoletto A; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, 35131 Padova, Italy.
Bizzotto G; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, 35131 Padova, Italy.
Cavozzi C; Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, 43124 Parma, Italy.
Malatesta M; Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, 43124 Parma, Italy.
Cavazzini D; Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, 43124 Parma, Italy.
Pasut G; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, 35131 Padova, Italy.
Percudani R; Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, 43124 Parma, Italy.

Biomolecules ; 11(3)2021 03 10.

Article en En | MEDLINE | ID: mdl-33802146

Asunto(s)

Actinas/metabolismo; Fibrosis Quística/terapia; Desoxirribonucleasa I/metabolismo; Desoxirribonucleasa I/uso terapéutico; Secuencia de Aminoácidos; Calcio/metabolismo; Dominio Catalítico; Secuencia Conservada; Cisteína/metabolismo; ADN/aislamiento & purificación; Desoxirribonucleasa I/química; Humanos; Moco; Oxidación-Reducción; Pichia/metabolismo; Plásmidos/aislamiento & purificación; Polietilenglicoles/química; Unión Proteica; Proteínas Recombinantes/aislamiento & purificación

Palabras clave

PEGylation; Pichia pastoris; cystic fibrosis; endonuclease; enzyme therapeutics; mucolytics

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Actinas / Fibrosis Quística / Desoxirribonucleasa I Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Biomolecules Año: 2021 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza

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