Increased erythrocyte susceptibility to lipid peroxidation in human Parkinson's disease.
Neurosci Lett
; 87(3): 307-10, 1988 May 03.
Article
en En
| MEDLINE
| ID: mdl-3380350
ABSTRACT
Recent evidence suggests that among the factors that lead to neurodegenerative changes in Parkinson's disease are stimulation of lipid peroxidation and deficiency of glutathione and glutathione peroxidase in substantia nigra. We have investigated the effect of neurodegenerative changes on plasma and erythrocytes of patients with Parkinson's disease and compared the results with those of age-matched controls. Both plasma lipid peroxide levels and erythrocyte susceptibility to lipid peroxidation were significantly increased in Parkinson's disease. Erythrocyte fragility tests revealed that in 35% of the patients there was increased fragility. In addition, erythrocyte catalase activities were not changed whereas glutathione levels and glutathione peroxidase activities were decreased in Parkinson's disease. Our results suggest that erythrocyte membrane integrity may be impaired in Parkinson's disease.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Enfermedad de Parkinson
/
Eritrocitos
/
Peróxidos Lipídicos
Límite:
Humans
Idioma:
En
Revista:
Neurosci Lett
Año:
1988
Tipo del documento:
Article
País de afiliación:
Turquía