Fungal Melanin and the Mammalian Immune System.
J Fungi (Basel)
; 7(4)2021 Mar 31.
Article
en En
| MEDLINE
| ID: mdl-33807336
ABSTRACT
Melanins are ubiquitous complex polymers that are commonly known in humans to cause pigmentation of our skin. Melanins are also present in bacteria, fungi, and helminths. In this review, we will describe the diverse interactions of fungal melanin with the mammalian immune system. We will particularly focus on Cryptococcus neoformans and also discuss other major melanotic pathogenic fungi. Melanin interacts with the immune system through diverse pathways, reducing the effectiveness of phagocytic cells, binding effector molecules and antifungals, and modifying complement and antibody responses.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
J Fungi (Basel)
Año:
2021
Tipo del documento:
Article
País de afiliación:
Estados Unidos