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Exopolysaccharide from Lactobacillus plantarum HY7714 Protects against Skin Aging through Skin-Gut Axis Communication.
Lee, Kippeum; Kim, Hyeon Ji; Kim, Soo A; Park, Soo-Dong; Shim, Jae-Jung; Lee, Jung-Lyoul.
Afiliación
  • Lee K; R&BD Center, Korea Yakult Co Ltd., 22, Giheungdanji-ro 24 beon-gil, Giheung-gu, Gyeonggi-do 17086, Korea.
  • Kim HJ; R&BD Center, Korea Yakult Co Ltd., 22, Giheungdanji-ro 24 beon-gil, Giheung-gu, Gyeonggi-do 17086, Korea.
  • Kim SA; R&BD Center, Korea Yakult Co Ltd., 22, Giheungdanji-ro 24 beon-gil, Giheung-gu, Gyeonggi-do 17086, Korea.
  • Park SD; R&BD Center, Korea Yakult Co Ltd., 22, Giheungdanji-ro 24 beon-gil, Giheung-gu, Gyeonggi-do 17086, Korea.
  • Shim JJ; R&BD Center, Korea Yakult Co Ltd., 22, Giheungdanji-ro 24 beon-gil, Giheung-gu, Gyeonggi-do 17086, Korea.
  • Lee JL; R&BD Center, Korea Yakult Co Ltd., 22, Giheungdanji-ro 24 beon-gil, Giheung-gu, Gyeonggi-do 17086, Korea.
Molecules ; 26(6)2021 Mar 16.
Article en En | MEDLINE | ID: mdl-33809637
ABSTRACT
Skin aging occurs inevitably as a natural result of physiological changes over time. In particular, solar exposure of the skin accounts for up to 90% of skin damage. Numerous studies have examined the ability of dietary constituents to prevent skin aging, and recent research has emphasized the role of functional probiotics in intestinal function and skin aging. However, the mechanism of the interactions between aging and probiotics has not been elucidated yet. The aim of this study was to determine the role of exopolysaccharides (EPS) produced by lactic acid bacteria (LAB) identified as Lactobacillus plantarum HY7714 in regulating tight junctions in intestinal epithelial cells and increasing moisture retention in human dermal fibroblasts cells. We observed that HY7714 EPS controlled intestinal tight junctions in Caco-2 cells by upregulating the genes encoding occludin-1 (OCL-1) and zonula occluden-1 (ZO-1). In addition, HY7714 EPS effectively improved UVB-induced cytotoxicity and hydration capacity in HS68 cells by downregulating production of metalloproteinases (MMPs) and reactive oxygen species (ROS). In summary, HY7714 EPS is an effective anti-aging molecule in skin and may have therapeutic potential against skin diseases and UVB-induced damage. Therefore, HY7714 EPS serves as a functional substance in skin-gut axis communication.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polisacáridos / Piel / Envejecimiento de la Piel / Sustancias Protectoras / Tracto Gastrointestinal / Lactobacillus plantarum Límite: Humans Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2021 Tipo del documento: Article Pais de publicación: CH / SUIZA / SUÍÇA / SWITZERLAND

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polisacáridos / Piel / Envejecimiento de la Piel / Sustancias Protectoras / Tracto Gastrointestinal / Lactobacillus plantarum Límite: Humans Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2021 Tipo del documento: Article Pais de publicación: CH / SUIZA / SUÍÇA / SWITZERLAND