Failure in all steps of hepatocellular carcinoma surveillance process is frequent in daily practice.
Ann Hepatol
; 25: 100344, 2021.
Article
en En
| MEDLINE
| ID: mdl-33819695
ABSTRACT
INTRODUCTION AND OBJECTIVES:
Failures at any step in the hepatocellular carcinoma (HCC) surveillance process can result in HCC diagnostic delays and associated worse prognosis. We aimed to estimate the prevalence of surveillance failure and its associated risk factors in patients with HCC in Argentina, considering threesteps:
1) recognition of at-risk patients, 2) implementation of HCC surveillance, 3) success of HCC surveillance.METHODS:
We performed a multi-center cross-sectional study of patients at-risk for HCC in Argentina seen between10.01.2018 and 10.30.2019. Multivariable logistic regression analysis was used to identify correlates of surveillance failure.RESULTS:
Of 301 included patients, the majority were male (74.8%) with a mean age of 64 years old. At the time of HCC diagnosis, 75 (25%) patients were unaware of their diagnosis of chronic liver disease, and only 130 (43%) patients were under HCC surveillance. Receipt of HCC surveillance was significantly associated with follow-up by a hepatologist. Of 119 patients with complete surveillance, surveillance failure occurred in 30 (25%) patients. Surveillance failure was significantly associated with alpha fetoprotein ≥20â¯ng/mL (OR 4.0, CI 95% 1.43-11.55).CONCLUSIONS:
HCC surveillance failure was frequent in all the evaluated steps. These data should help guide strategies to improve the implementation and results of HCC surveillance in our country.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Carcinoma Hepatocelular
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Detección Precoz del Cáncer
/
Neoplasias Hepáticas
Tipo de estudio:
Clinical_trials
/
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
/
Prevalence_studies
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Prognostic_studies
/
Risk_factors_studies
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Screening_studies
Aspecto:
Determinantes_sociais_saude
Límite:
Aged
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Female
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Humans
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Male
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Middle aged
País/Región como asunto:
America do sul
/
Argentina
Idioma:
En
Revista:
Ann Hepatol
Asunto de la revista:
GASTROENTEROLOGIA
Año:
2021
Tipo del documento:
Article