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Photoactivated nanomotors via aggregation induced emission for enhanced phototherapy.
Cao, Shoupeng; Shao, Jingxin; Wu, Hanglong; Song, Shidong; De Martino, Maria Teresa; Pijpers, Imke A B; Friedrich, Heiner; Abdelmohsen, Loai K E A; Williams, David S; van Hest, Jan C M.
Afiliación
  • Cao S; Bio-Organic Chemistry, Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, MB, Eindhoven, The Netherlands.
  • Shao J; Bio-Organic Chemistry, Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, MB, Eindhoven, The Netherlands.
  • Wu H; Bio-Organic Chemistry, Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, MB, Eindhoven, The Netherlands.
  • Song S; Bio-Organic Chemistry, Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, MB, Eindhoven, The Netherlands.
  • De Martino MT; Bio-Organic Chemistry, Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, MB, Eindhoven, The Netherlands.
  • Pijpers IAB; Bio-Organic Chemistry, Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, MB, Eindhoven, The Netherlands.
  • Friedrich H; Center for Multiscale Electron Microscopy (CMEM) and Department of Chemical Engineering and Chemistry, Physical Chemistry, Institute for Complex Molecular Systems (ICMS), Eindhoven University of Technology, MB, Eindhoven, The Netherlands.
  • Abdelmohsen LKEA; Bio-Organic Chemistry, Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, MB, Eindhoven, The Netherlands. l.k.e.a.abdelmohsen@tue.nl.
  • Williams DS; Department of Chemistry, College of Science, Swansea University, Swansea, UK. d.s.williams@swansea.ac.uk.
  • van Hest JCM; Bio-Organic Chemistry, Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, MB, Eindhoven, The Netherlands. j.c.m.v.hest@tue.nl.
Nat Commun ; 12(1): 2077, 2021 04 06.
Article en En | MEDLINE | ID: mdl-33824321
Aggregation-induced emission (AIE) has, since its discovery, become a valuable tool in the field of nanoscience. AIEgenic molecules, which display highly stable fluorescence in an assembled state, have applications in various biomedical fields-including photodynamic therapy. Engineering structure-inherent, AIEgenic nanomaterials with motile properties is, however, still an unexplored frontier in the evolution of this potent technology. Here, we present phototactic/phototherapeutic nanomotors where biodegradable block copolymers decorated with AIE motifs can transduce radiant energy into motion and enhance thermophoretic motility driven by an asymmetric Au nanoshell. The hybrid nanomotors can harness two photon near-infrared radiation, triggering autonomous propulsion and simultaneous phototherapeutic generation of reactive oxygen species. The potential of these nanomotors to be applied in photodynamic therapy is demonstrated in vitro, where near-infrared light directed motion and reactive oxygen species induction synergistically enhance efficacy with a high level of spatial control.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fototerapia / Nanopartículas / Luz Límite: Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2021 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fototerapia / Nanopartículas / Luz Límite: Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2021 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Reino Unido