Carbonic anhydrase inhibition improves pulmonary artery reactivity and nitric oxide-mediated relaxation in sugen-hypoxia model of pulmonary hypertension.

Christou, Helen; Michael, Zoe; Spyropoulos, Fotios; Chen, Yunfei; Rong, Dan; Khalil, Raouf A

Christou, Helen; Michael, Zoe; Spyropoulos, Fotios; Chen, Yunfei; Rong, Dan; Khalil, Raouf A.

Afiliación

Christou H; Department of Pediatric Newborn Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
Michael Z; Harvard Medical School, Boston, Massachusetts.
Spyropoulos F; Department of Pediatric Newborn Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
Chen Y; Department of Pediatric Newborn Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
Rong D; Harvard Medical School, Boston, Massachusetts.
Khalil RA; Division of Vascular and Endovascular Surgery, Brigham and Women's Hospital, Boston, Massachusetts.

Am J Physiol Regul Integr Comp Physiol ; 320(6): R835-R850, 2021 06 01.

Article en En | MEDLINE | ID: mdl-33826428

Asunto(s)

Inhibidores de Anhidrasa Carbónica/farmacología; Hipertensión Pulmonar/fisiopatología; Músculo Liso Vascular/fisiopatología; Arteria Pulmonar/fisiopatología; Animales; Hipoxia/fisiopatología; Masculino; Arterias Mesentéricas/fisiopatología; Óxido Nítrico/metabolismo; Óxido Nítrico/farmacología; Ratas Sprague-Dawley; Vasodilatación/efectos de los fármacos

Palabras clave

endothelium; hypertension; nitric oxide; smooth muscle; vascular

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Arteria Pulmonar / Inhibidores de Anhidrasa Carbónica / Hipertensión Pulmonar / Músculo Liso Vascular Límite: Animals Idioma: En Revista: Am J Physiol Regul Integr Comp Physiol Asunto de la revista: FISIOLOGIA Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos

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