Cues conditioned to withdrawal and negative reinforcement: Neglected but key motivational elements driving opioid addiction.
Sci Adv
; 7(15)2021 04.
Article
en En
| MEDLINE
| ID: mdl-33827822
ABSTRACT
Opioid use disorder (OUD) is a debilitating disorder that affects millions of people. Neutral cues can acquire motivational properties when paired with the positive emotional effects of drug intoxication to stimulate relapse. However, much less research has been devoted to cues that become conditioned to the aversive effects of opioid withdrawal. We argue that environmental stimuli promote motivation for opioids when cues are paired with withdrawal (conditioned withdrawal) and generate opioid consumption to terminate conditioned withdrawal (conditioned negative reinforcement). We review evidence that cues associated with pain drive opioid consumption, as patients with chronic pain may misuse opioids to escape physical and emotional pain. We highlight sex differences in withdrawal-induced stress reactivity and withdrawal cue processing and discuss neurocircuitry that may underlie withdrawal cue processing in dependent individuals. These studies highlight the importance of studying cues associated with withdrawal in dependent individuals and point to areas for exploration in OUD research.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Síndrome de Abstinencia a Sustancias
/
Dolor Crónico
/
Trastornos Relacionados con Opioides
Límite:
Female
/
Humans
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Male
Idioma:
En
Revista:
Sci Adv
Año:
2021
Tipo del documento:
Article