Characterization of the prion protein gene in axis deer (Axis axis) and implications for susceptibility to chronic wasting disease.
Prion
; 15(1): 44-52, 2021 12.
Article
en En
| MEDLINE
| ID: mdl-33834939
ABSTRACT
Axis deer (Axis axis) occur both in captivity and free-ranging populations in portions of North America, but to-date, no data exist pertaining to the species' susceptibility to CWD. We sequenced the prion protein gene (PRNP) from axis deer. We then compared axis deer PrPC sequences and amino acid polymorphisms to those of CWD susceptible species. A single PRNP allele with no evidence of intraspecies variation was identified in axis deer that indicates axis deer PRNP is most similar to North American elk (Cervus canadensis) PRNP. Therefore, axis deer may be susceptible to CWD. We recommend proactively increasing CWD surveillance for axis deer, particularly where CWD has been detected and axis deer are sympatric with native North American CWD susceptible species.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Priones
/
Ciervos
/
Enfermedad Debilitante Crónica
Límite:
Animals
Idioma:
En
Revista:
Prion
Asunto de la revista:
BIOQUIMICA
Año:
2021
Tipo del documento:
Article