Developing a databank for multiple transfusion patients: Rh antigen and phenotype distribution among 3000 regular blood donors in Iran.
Transfus Apher Sci
; 60(3): 103124, 2021 Jun.
Article
en En
| MEDLINE
| ID: mdl-33839013
ABSTRACT
BACKGROUND:
Rhesus (Rh) blood group system is clinically the most significant protein-based grouping system. The Rh system is of vital importance in blood transfusion, and incompatibility between the donor and recipient leads to alloimmunization. Alloimmunization is commonly seen in multiple-transfusion recipients (e.g. thalassemia patients). There are a few studies about the prevalence of Rh antigens, except for D, in Iran; and regarding the high prevalence of thalassemia in the country, in this study we have determined antigens and phenotypes of the Rh among population of regular blood donors with the aim of developing a detailed Rh databank. MATERIALS ANDMETHODS:
This cross-sectional study randomly enrolled 3000 regular blood donors from three provinces of Sistan-Balouchestan, Khuzestan and Gilan in Iran, from September 2018 to May 2019. A fully automated system, based on hemagglutination, was used to Rh typing of blood samples.RESULTS:
The prevalence of Rh antigens were as follows D 88.9 %; E 30.9 %; C 74.1 %; e 96.2 %; and c 72.8 %. The most common antigen and phenotype were "e" and R1r (DCcee), respectively.CONCLUSION:
Due to the high rate of alloimmunization incidence against Rh blood group antigens among multiple transfusion recipients, development of regular blood donor's Rh databank can facilitate extensive matching for the Rh antigens and it likely reduces the risk of alloimmunization.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Sistema del Grupo Sanguíneo Rh-Hr
/
Transfusión Sanguínea
/
Bases de Datos Factuales
Tipo de estudio:
Clinical_trials
/
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Límite:
Adult
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Female
/
Humans
/
Male
País/Región como asunto:
Asia
Idioma:
En
Revista:
Transfus Apher Sci
Asunto de la revista:
HEMATOLOGIA
Año:
2021
Tipo del documento:
Article