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Fructose intolerance is not associated with malabsorption in patients with functional gastrointestinal disorders.
Wilder-Smith, Clive; Lee, Sze Han; Olesen, Søren Schou; Low, Jing Yi; Kioh, Dorinda Yan Qin; Ferraris, Ronaldo; Materna, Andrea; Chan, Eric Chun Yong.
Afiliación
  • Wilder-Smith C; Gastroenterology Group Practice, Brain-Gut Research Group, Bern, Switzerland.
  • Lee SH; Department of Pharmacy, National University of Singapore, Singapore City, Singapore.
  • Olesen SS; Department of Gastroenterology and Hepatology, Mech-Sense, Aalborg University Hospital, Aalborg, Denmark.
  • Low JY; Department of Pharmacy, National University of Singapore, Singapore City, Singapore.
  • Kioh DYQ; Department of Pharmacy, National University of Singapore, Singapore City, Singapore.
  • Ferraris R; Department of Pharmacology & Physiology, New Jersey Medical School, Newark, NJ, USA.
  • Materna A; Gastroenterology Group Practice, Brain-Gut Research Group, Bern, Switzerland.
  • Chan ECY; Department of Pharmacy, National University of Singapore, Singapore City, Singapore.
Neurogastroenterol Motil ; 33(12): e14150, 2021 12.
Article en En | MEDLINE | ID: mdl-33844393
BACKGROUND: Symptoms following fructose ingestion, or fructose intolerance, are common in patients with functional gastrointestinal disorders (FGID) and are generally attributed to intestinal malabsorption. The relationships between absorption, symptoms, and intestinal gas production following fructose ingestion were studied in patients with FGID. METHODS: Thirty FGID patients ingested a single dose of fructose 35 g or water in a randomized, double-blind, crossover study. Blood and breath gas samples were collected, and gastrointestinal symptoms rated. Plasma fructose metabolites and short-chain fatty acids were quantified by targeted liquid chromatography-tandem mass spectrometry. Patients were classified as fructose intolerant or tolerant based on symptoms following fructose ingestion. KEY RESULTS: The median (IQR) areas under the curve of fructose plasma concentrations within the first 2 h (AUC0-2 h ) after fructose ingestion were similar for patients with and without fructose intolerance (578 (70) µM·h vs. 564 (240) µM·h, respectively, p = 0.39), as well as for the main fructose metabolites. There were no statistically significant correlations between the AUC0-2 h of fructose or its metabolites concentrations and the AUCs of symptoms, breath hydrogen, and breath methane. However, the AUCs of symptoms correlated significantly and positively with the AUC0-2 h of hydrogen and methane breath concentrations (r = 0.73, r = 0.62, respectively), and the AUCs of hydrogen and methane concentrations were greater in the fructose-intolerant than in the fructose-tolerant patients after fructose ingestion (p ≤ 0.02). CONCLUSIONS & INFERENCES: Fructose intolerance in FGID is not related to post-ingestion plasma concentrations of fructose and its metabolites. Factors other than malabsorption, such as altered gut microbiota or sensory function, may be important mechanisms.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Intolerancia a la Fructosa / Enfermedades Gastrointestinales / Síndromes de Malabsorción Tipo de estudio: Clinical_trials / Diagnostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Neurogastroenterol Motil Asunto de la revista: GASTROENTEROLOGIA / NEUROLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Intolerancia a la Fructosa / Enfermedades Gastrointestinales / Síndromes de Malabsorción Tipo de estudio: Clinical_trials / Diagnostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Neurogastroenterol Motil Asunto de la revista: GASTROENTEROLOGIA / NEUROLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Reino Unido