Intellective and stimuli-responsive drug delivery systems in eyes.
Int J Pharm
; 602: 120591, 2021 Jun 01.
Article
en En
| MEDLINE
| ID: mdl-33845152
ABSTRACT
Stimuli-responsive drug delivery systems have attracted widespread attention in recent years since they can control drug release in a spatiotemporal manner and can achieve tunable drug release according to patient's physiological or pathological condition. In this review, we briefly introduce the drug delivery barriers and drug delivery systems in the anterior and posterior segment of eyes, and collect the recent advances in stimuli-responsive drug delivery systems in eyes for controlled drug release in response to exogenous stimuli (ultrasound, magnetic stimulus, electrical stimulus, and light) or endogenous stimuli (enzyme, active oxygen species, temperature, ions, and pH). In addition, the design and mechanisms of the stimuli-responsive drug delivery systems have been summarized in this review, and the advantages and limitations are also briefly discussed.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Preparaciones Farmacéuticas
/
Sistemas de Liberación de Medicamentos
Límite:
Humans
Idioma:
En
Revista:
Int J Pharm
Año:
2021
Tipo del documento:
Article
País de afiliación:
China