Adiponectin-mimetic novel nonapeptide rescues aberrant neuronal metabolic-associated memory deficits in Alzheimer's disease.

Ali, Tahir; Rehman, Shafiq Ur; Khan, Amjad; Badshah, Haroon; Abid, Noman Bin; Kim, Min Woo; Jo, Myeung Hoon; Chung, Seung Soo; Lee, Hyoung-Gon; Rutten, Bart P F; Kim, Myeong Ok

Ali, Tahir; Rehman, Shafiq Ur; Khan, Amjad; Badshah, Haroon; Abid, Noman Bin; Kim, Min Woo; Jo, Myeung Hoon; Chung, Seung Soo; Lee, Hyoung-Gon; Rutten, Bart P F; Kim, Myeong Ok.

Afiliación

Ali T; Division of Applied Life Science (BK 21 Four), College of Natural Science, Gyeongsang National University, Jinju, 52828, Republic of Korea.
Rehman SU; Division of Applied Life Science (BK 21 Four), College of Natural Science, Gyeongsang National University, Jinju, 52828, Republic of Korea.
Khan A; Division of Applied Life Science (BK 21 Four), College of Natural Science, Gyeongsang National University, Jinju, 52828, Republic of Korea.
Badshah H; Division of Applied Life Science (BK 21 Four), College of Natural Science, Gyeongsang National University, Jinju, 52828, Republic of Korea.
Abid NB; Division of Applied Life Science (BK 21 Four), College of Natural Science, Gyeongsang National University, Jinju, 52828, Republic of Korea.
Kim MW; Division of Applied Life Science (BK 21 Four), College of Natural Science, Gyeongsang National University, Jinju, 52828, Republic of Korea.
Jo MH; Division of Applied Life Science (BK 21 Four), College of Natural Science, Gyeongsang National University, Jinju, 52828, Republic of Korea.
Chung SS; Department of Physiology, College of Medicine, Yonsei University, Seoul, 120-752, Republic of Korea.
Lee HG; Department of Biology, The University of Texas at San Antonio, San Antonio, USA.
Rutten BPF; Translational Neuroscience and Psychiatry, School for Mental Health and Neuroscience (MHeNs), Maastricht University Medical Centre, Maastricht, Netherlands.
Kim MO; Division of Applied Life Science (BK 21 Four), College of Natural Science, Gyeongsang National University, Jinju, 52828, Republic of Korea. mokim@gnu.ac.kr.

Mol Neurodegener ; 16(1): 23, 2021 04 13.

Article en En | MEDLINE | ID: mdl-33849621

Asunto(s)

Enfermedad de Alzheimer/tratamiento farmacológico; Trastornos de la Memoria/prevención & control; Fármacos Neuroprotectores/farmacología; Receptores de Adiponectina/antagonistas & inhibidores; Proteínas Quinasas Activadas por AMP/metabolismo; Adiponectina/deficiencia; Enfermedad de Alzheimer/metabolismo; Enfermedad de Alzheimer/psicología; Péptidos beta-Amiloides/genética; Animales; Línea Celular Tumoral; Evaluación Preclínica de Medicamentos; Humanos; Resistencia a la Insulina; Masculino; Aprendizaje por Laberinto; Trastornos de la Memoria/tratamiento farmacológico; Trastornos de la Memoria/etiología; Ratones; Ratones Endogámicos C57BL; Ratones Noqueados; Ratones Transgénicos; Neuronas/efectos de los fármacos; Fármacos Neuroprotectores/uso terapéutico; Presenilina-1/genética; Interferencia de ARN; ARN Interferente Pequeño/genética; Receptores de Adiponectina/genética; Transducción de Señal

Palabras clave

AdipoR1/AMPK signaling; Adiponectin-mimetic novel nonapeptide (Os-pep); Alzheimer's disease (AD); Brain metabolic disorders; Insulin signaling; Neuronal adiponectin receptor 1 (AdipoR1); Neuronal insulin resistance; Synaptic and memory deficits

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fármacos Neuroprotectores / Receptores de Adiponectina / Enfermedad de Alzheimer / Trastornos de la Memoria Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Animals / Humans / Male Idioma: En Revista: Mol Neurodegener Año: 2021 Tipo del documento: Article

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google