Brd4-bound enhancers drive cell-intrinsic sex differences in glioblastoma.

Kfoury, Najla; Qi, Zongtai; Prager, Briana C; Wilkinson, Michael N; Broestl, Lauren; Berrett, Kristopher C; Moudgil, Arnav; Sankararaman, Sumithra; Chen, Xuhua; Gertz, Jason; Rich, Jeremy N; Mitra, Robi D; Rubin, Joshua B

Kfoury, Najla; Qi, Zongtai; Prager, Briana C; Wilkinson, Michael N; Broestl, Lauren; Berrett, Kristopher C; Moudgil, Arnav; Sankararaman, Sumithra; Chen, Xuhua; Gertz, Jason; Rich, Jeremy N; Mitra, Robi D; Rubin, Joshua B.

Afiliación

Kfoury N; Department of Pediatrics, School of Medicine, Washington University in St. Louis, St. Louis, MO 63110.
Qi Z; Department of Neurological Surgery, University of California San Diego, La Jolla, CA 92037.
Prager BC; Department of Genetics, School of Medicine, Washington University in St. Louis, St. Louis, MO 63110.
Wilkinson MN; Center for Genome Sciences and Systems Biology, Washington University in St. Louis, St. Louis, MO 63110.
Broestl L; Division of Regenerative Medicine, Department of Medicine, University of California San Diego, La Jolla, CA 92037.
Berrett KC; Cleveland Clinic Lerner College of Medicine, Cleveland, OH 44195.
Moudgil A; Department of Genetics, School of Medicine, Washington University in St. Louis, St. Louis, MO 63110.
Sankararaman S; Center for Genome Sciences and Systems Biology, Washington University in St. Louis, St. Louis, MO 63110.
Chen X; Department of Pediatrics, School of Medicine, Washington University in St. Louis, St. Louis, MO 63110.
Gertz J; Medical Scientist Training Program, School of Medicine, Washington University in St. Louis, St. Louis, MO 63110.
Rich JN; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112.
Mitra RD; Department of Genetics, School of Medicine, Washington University in St. Louis, St. Louis, MO 63110.
Rubin JB; Center for Genome Sciences and Systems Biology, Washington University in St. Louis, St. Louis, MO 63110.

Proc Natl Acad Sci U S A ; 118(16)2021 04 20.

Article en En | MEDLINE | ID: mdl-33850013

Asunto(s)

Proteínas de Ciclo Celular/metabolismo; Glioblastoma/metabolismo; Proteínas Nucleares/metabolismo; Factores Sexuales; Factores de Transcripción/metabolismo; Animales; Neoplasias Encefálicas/genética; Neoplasias Encefálicas/metabolismo; Línea Celular Tumoral; Proliferación Celular/genética; Femenino; Expresión Génica/genética; Regulación Neoplásica de la Expresión Génica/genética; Glioblastoma/genética; Histonas/metabolismo; Humanos; Masculino; Ratones; Proteínas Nucleares/fisiología; Unión Proteica; Proteínas Proto-Oncogénicas c-myc/metabolismo; Secuencias Reguladoras de Ácidos Nucleicos/genética; Caracteres Sexuales; Factores de Transcripción/fisiología; Proteína p53 Supresora de Tumor/metabolismo

Palabras clave

BET inhibitors; Brd4-bound enhancers; glioblastoma; sex differences; sex-specific transcriptional programs

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Factores de Transcripción / Proteínas Nucleares / Factores Sexuales / Glioblastoma / Proteínas de Ciclo Celular Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans / Male Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos

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