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Inhibition of PDE4 by apremilast attenuates skin fibrosis through directly suppressing activation of M1 and T cells.
Lu, Qiu-Kai; Fan, Chen; Xiang, Cai-Gui; Wu, Bing; Lu, Hui-Min; Feng, Chun-Lan; Yang, Xiao-Qian; Li, Heng; Tang, Wei.
Afiliación
  • Lu QK; Laboratory of Anti-inflammation and Immunopharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
  • Fan C; School of Pharmacy, University of Chinese Academy of Sciences, Beijing, 100049, China.
  • Xiang CG; Laboratory of Anti-inflammation and Immunopharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
  • Wu B; Laboratory of Anti-inflammation and Immunopharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
  • Lu HM; School of Pharmacy, University of Chinese Academy of Sciences, Beijing, 100049, China.
  • Feng CL; Laboratory of Anti-inflammation and Immunopharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
  • Yang XQ; School of Pharmacy, University of Chinese Academy of Sciences, Beijing, 100049, China.
  • Li H; Laboratory of Anti-inflammation and Immunopharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
  • Tang W; School of Pharmacy, University of Chinese Academy of Sciences, Beijing, 100049, China.
Acta Pharmacol Sin ; 43(2): 376-386, 2022 Feb.
Article en En | MEDLINE | ID: mdl-33850274
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piel / Talidomida / Linfocitos T / Inhibidores de Fosfodiesterasa 4 / Macrófagos Límite: Animals Idioma: En Revista: Acta Pharmacol Sin Asunto de la revista: FARMACOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piel / Talidomida / Linfocitos T / Inhibidores de Fosfodiesterasa 4 / Macrófagos Límite: Animals Idioma: En Revista: Acta Pharmacol Sin Asunto de la revista: FARMACOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos