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Discovery of New Potent Positive Allosteric Modulators of Dopamine D2 Receptors: Insights into the Bioisosteric Replacement of Proline to 3-Furoic Acid in the Melanostatin Neuropeptide.
Sampaio-Dias, Ivo E; Reis-Mendes, Ana; Costa, Vera Marisa; García-Mera, Xerardo; Brea, José; Loza, María Isabel; Pires-Lima, Beatriz L; Alcoholado, Cristina; Algarra, Manuel; Rodríguez-Borges, José E.
Afiliación
  • Sampaio-Dias IE; LAQV/REQUIMTE, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, 4169-007 Porto, Portugal.
  • Reis-Mendes A; UCIBIO, REQUIMTE, Laboratory of Toxicology, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.
  • Costa VM; UCIBIO, REQUIMTE, Laboratory of Toxicology, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.
  • García-Mera X; Department of Organic Chemistry, Faculty of Pharmacy, University of Santiago de Compostela, E-15782 Santiago de Compostela, Spain.
  • Brea J; Innopharma Screening Platform, Biofarma Research group, Centre of Research in Molecular Medicine and Chronic Diseases (CIMUS), University of Santiago de Compostela, E-15782 Santiago de Compostela, Spain.
  • Loza MI; Innopharma Screening Platform, Biofarma Research group, Centre of Research in Molecular Medicine and Chronic Diseases (CIMUS), University of Santiago de Compostela, E-15782 Santiago de Compostela, Spain.
  • Pires-Lima BL; LAQV/REQUIMTE, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, 4169-007 Porto, Portugal.
  • Alcoholado C; Department of Cellular Biology, Genetics and Physiology, Faculty of Sciences, University of Málaga, Campus de Teatinos, 29071 Málaga, Spain.
  • Algarra M; Department of Inorganic Chemistry, Faculty of Sciences, University of Málaga, Campus de Teatinos, 29071 Málaga, Spain.
  • Rodríguez-Borges JE; LAQV/REQUIMTE, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, 4169-007 Porto, Portugal.
J Med Chem ; 64(9): 6209-6220, 2021 05 13.
Article en En | MEDLINE | ID: mdl-33861612
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hormona Inhibidora de la Liberación de MSH / Prolina / Diseño de Fármacos / Receptores de Dopamina D2 / Furanos Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2021 Tipo del documento: Article País de afiliación: Portugal
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hormona Inhibidora de la Liberación de MSH / Prolina / Diseño de Fármacos / Receptores de Dopamina D2 / Furanos Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2021 Tipo del documento: Article País de afiliación: Portugal