Synthesis and evaluation of multi-target-directed ligands with BACE-1 inhibitory and Nrf2 agonist activities as potential agents against Alzheimer's disease.

Qu, Lailiang; Ji, Limei; Wang, Cheng; Luo, Heng; Li, Shang; Peng, Wan; Yin, Fucheng; Lu, Dehua; Liu, Xingchen; Kong, Lingyi; Wang, Xiaobing

Qu, Lailiang; Ji, Limei; Wang, Cheng; Luo, Heng; Li, Shang; Peng, Wan; Yin, Fucheng; Lu, Dehua; Liu, Xingchen; Kong, Lingyi; Wang, Xiaobing.

Afiliación

Qu L; Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 210009, China.
Ji L; Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 210009, China.
Wang C; Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 210009, China.
Luo H; Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 210009, China.
Li S; Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 210009, China.
Peng W; Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 210009, China.
Yin F; Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 210009, China.
Lu D; Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 210009, China.
Liu X; Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 210009, China.
Kong L; Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 210009, China. Electronic address: cpu_lykong@126.com.
Wang X; Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 210009, China. Electronic address: xbwang@cpu.edu.cn.

Eur J Med Chem ; 219: 113441, 2021 Jul 05.

Article en En | MEDLINE | ID: mdl-33862517

Asunto(s)

Secretasas de la Proteína Precursora del Amiloide/antagonistas & inhibidores; Ácido Aspártico Endopeptidasas/antagonistas & inhibidores; Ligandos; Factor 2 Relacionado con NF-E2/antagonistas & inhibidores; Fármacos Neuroprotectores/síntesis química; Enfermedad de Alzheimer/tratamiento farmacológico; Secretasas de la Proteína Precursora del Amiloide/metabolismo; Péptidos beta-Amiloides/metabolismo; Antioxidantes/metabolismo; Ácido Aspártico Endopeptidasas/metabolismo; Azoles/química; Azoles/metabolismo; Azoles/farmacología; Azoles/uso terapéutico; Sitios de Unión; Barrera Hematoencefálica/efectos de los fármacos; Barrera Hematoencefálica/metabolismo; Óxidos S-Cíclicos/química; Óxidos S-Cíclicos/metabolismo; Óxidos S-Cíclicos/farmacología; Óxidos S-Cíclicos/uso terapéutico; Diseño de Fármacos; Humanos; Interleucina-6/metabolismo; Isoindoles; Mitocondrias/efectos de los fármacos; Mitocondrias/metabolismo; Simulación del Acoplamiento Molecular; Factor 2 Relacionado con NF-E2/metabolismo; Fármacos Neuroprotectores/metabolismo; Fármacos Neuroprotectores/farmacología; Fármacos Neuroprotectores/uso terapéutico; Compuestos de Organoselenio/química; Compuestos de Organoselenio/metabolismo; Compuestos de Organoselenio/farmacología; Compuestos de Organoselenio/uso terapéutico; Estrés Oxidativo/efectos de los fármacos; Fragmentos de Péptidos/metabolismo; Especies Reactivas de Oxígeno/metabolismo; Selenio/química; Transducción de Señal/efectos de los fármacos; Tiadiazinas/química; Tiadiazinas/metabolismo; Tiadiazinas/farmacología; Tiadiazinas/uso terapéutico

Palabras clave

Alzheimer's disease; Anti-inflammatory; Antioxidant; BACE-1; Neuroprotection; Nrf2

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácido Aspártico Endopeptidasas / Fármacos Neuroprotectores / Factor 2 Relacionado con NF-E2 / Secretasas de la Proteína Precursora del Amiloide / Ligandos Tipo de estudio: Prognostic_studies Idioma: En Revista: Eur J Med Chem Año: 2021 Tipo del documento: Article País de afiliación: China

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