Different sensitivity of action potential generation to the rate of depolarization in vagal afferent A-fiber versus C-fiber neurons.
J Neurophysiol
; 125(5): 2000-2012, 2021 05 01.
Article
en En
| MEDLINE
| ID: mdl-33881911
ABSTRACT
This study demonstrates that the action potential discharge in vagal afferent A-fiber neurons is about 20 times more sensitive to the rate of membrane depolarization compared to C-fiber neurons. The sensitivity of action potential generation to the depolarization rate in vagal sensory neurons is independent of the intensity of current stimuli but nearly abrogated by inhibiting the D-type potassium channel. These findings help better understand the mechanisms that control the activation of vagal afferent nerves.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Potenciales de Acción
/
Fibras Nerviosas Amielínicas
/
Canales de Potasio de la Superfamilia Shaker
/
Fibras Nerviosas Mielínicas
/
Neuronas Aferentes
/
Ganglio Nudoso
Tipo de estudio:
Diagnostic_studies
Límite:
Animals
Idioma:
En
Revista:
J Neurophysiol
Año:
2021
Tipo del documento:
Article
País de afiliación:
Estados Unidos