Genetic changes and growth promotion of glioblastoma by magnetic nanoparticles and a magnetic field.
Nanomedicine (Lond)
; 16(10): 787-800, 2021 04.
Article
en En
| MEDLINE
| ID: mdl-33890494
ABSTRACT
Aim:
To confirm the biological effects of manganese ferrite magnetic nanoparticles (MFMNPs) and an external magnetic field on glioblastoma cells.Methods:
U-87MG glioblastoma cells were prepared, into which the uptake of MFMNPs was high. The cells were then exposed to an external magnetic field using a neodymium magnet in vitro and in vivo.Results:
LRP6 and TCF7 mRNA levels involved in the Wnt/ß-catenin signaling pathway were elevated by the influence of MFMNPs and the external magnetic field. MFMNPs and the external magnetic field also accelerated tumor growth by approximately 7 days and decreased survival rates in animal experiments.Conclusion:
When MFMNPs and an external magnetic field are applied for a long time on glioblastoma cells, mRNA expression related to Wnt/ß-catenin signaling is increased and tumor growth is promoted.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Glioblastoma
/
Nanopartículas de Magnetita
Límite:
Animals
Idioma:
En
Revista:
Nanomedicine (Lond)
Año:
2021
Tipo del documento:
Article