Development and intercomparison of single and multicompartment physiologically-based toxicokinetic models: Implications for model selection and tiered modeling frameworks.

Armitage, James M; Hughes, Lauren; Sangion, Alessandro; Arnot, Jon A

Armitage, James M; Hughes, Lauren; Sangion, Alessandro; Arnot, Jon A.

Afiliación

Armitage JM; AES Armitage Environmental Sciences, Inc., Ottawa, Ontario K1L 8C3, Canada; Department of Physical and Environmental Sciences, University of Toronto Scarborough, Toronto, Ontario M1C 1A4, Canada. Electronic address: james.armitage@utoronto.ca.
Hughes L; ARC Arnot Research and Consulting, Toronto, Ontario M4M 1W4, Canada.
Sangion A; Department of Physical and Environmental Sciences, University of Toronto Scarborough, Toronto, Ontario M1C 1A4, Canada; ARC Arnot Research and Consulting, Toronto, Ontario M4M 1W4, Canada.
Arnot JA; Department of Physical and Environmental Sciences, University of Toronto Scarborough, Toronto, Ontario M1C 1A4, Canada; ARC Arnot Research and Consulting, Toronto, Ontario M4M 1W4, Canada; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

Environ Int ; 154: 106557, 2021 09.

Article en En | MEDLINE | ID: mdl-33892222

Asunto(s)

Modelos Biológicos; Compuestos Orgánicos; Adulto; Humanos; Masculino; Toxicocinética

Palabras clave

Biotransformation; Chemical assessment; Modeling; Toxicokinetics

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Compuestos Orgánicos / Modelos Biológicos Tipo de estudio: Prognostic_studies Límite: Adult / Humans / Male Idioma: En Revista: Environ Int Año: 2021 Tipo del documento: Article Pais de publicación: Países Bajos

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