How NS1 Antibodies Prevent Severe Flavivirus Disease.

Ooi, Justin S G; Lok, Shee-Mei

Ooi, Justin S G; Lok, Shee-Mei.

Afiliación

Ooi JSG; Programme in Emerging Infectious Disease, Duke-National University of Singapore Medical School, Singapore 169857, Singapore; Center for BioImaging Sciences, National University of Singapore, Singapore 117557, Singapore.
Lok SM; Programme in Emerging Infectious Disease, Duke-National University of Singapore Medical School, Singapore 169857, Singapore; Center for BioImaging Sciences, National University of Singapore, Singapore 117557, Singapore; Department of Biological Sciences, National University of Singapore, Singapore 117557, Singapore. Electronic address: sheemei.lok@duke-nus.edu.sg.

Trends Biochem Sci ; 46(7): 519-521, 2021 07.

Article en En | MEDLINE | ID: mdl-33895084

ABSTRACT

ABSTRACT

The flavivirus genus consists of several major human pathogens including dengue (DENV) and Zika viruses. The flavivirus nonstructural protein 1 (NS1) plays an important role in disease progression, for example, in the development of severe dengue disease. Anti-NS1 antibodies have been shown to confer protection, and two new studies by Biering et al. and Modhiran et al. on the structure of NS1antibody complexes reveal their mechanism of neutralization.

Asunto(s)

Virus del Dengue; Dengue; Flavivirus; Infección por el Virus Zika; Virus Zika; Anticuerpos Antivirales; Virus del Dengue/inmunología; Humanos; Proteínas no Estructurales Virales

Palabras clave

antibody; flavivirus; nonstructural protein 1 (NS1); structural biology

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dengue / Virus del Dengue / Flavivirus / Virus Zika / Infección por el Virus Zika Límite: Humans Idioma: En Revista: Trends Biochem Sci Año: 2021 Tipo del documento: Article País de afiliación: Singapur

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