Development, Characterization and Potential Applications of a Multicellular Spheroidal Human Blood-Brain Barrier Model Integrating Three Conditionally Immortalized Cell Lines.

Kitamura, Keita; Umehara, Kenta; Ito, Ryo; Yamaura, Yoshiyuki; Komori, Takafumi; Morio, Hanae; Akita, Hidetaka; Furihata, Tomomi

Kitamura, Keita; Umehara, Kenta; Ito, Ryo; Yamaura, Yoshiyuki; Komori, Takafumi; Morio, Hanae; Akita, Hidetaka; Furihata, Tomomi.

Afiliación

Kitamura K; Laboratory of DDS Design and Drug Disposition, Graduate School of Pharmaceutical Sciences, Chiba University.
Umehara K; Laboratory of Clinical Pharmacy & Experimental Therapeutics, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences.
Ito R; Laboratory of DDS Design and Drug Disposition, Graduate School of Pharmaceutical Sciences, Chiba University.
Yamaura Y; Research Center of Neurology, Ono Pharmaceutical Co., Ltd.
Komori T; Pharmacokinetic Research Laboratories, Ono Pharmaceutical Co., Ltd.
Morio H; Drug Metabolism and Pharmacokinetics Tsukuba, Tsukuba Research Laboratories, Eisai Co., Ltd.
Akita H; Laboratory of Clinical Pharmacy & Experimental Therapeutics, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences.
Furihata T; Laboratory of DDS Design and Drug Disposition, Graduate School of Pharmaceutical Sciences, Chiba University.

Biol Pharm Bull ; 44(7): 984-991, 2021 Jul 01.

Article en En | MEDLINE | ID: mdl-33896887

Asunto(s)

Barrera Hematoencefálica/fisiología; Esferoides Celulares/metabolismo; Astrocitos/metabolismo; Transporte Biológico/fisiología; Barrera Hematoencefálica/efectos de los fármacos; Encéfalo/metabolismo; Línea Celular; Técnicas de Cocultivo; Células Endoteliales/metabolismo; Humanos; Técnicas In Vitro; Inflamación/metabolismo; Proteínas de Transporte de Membrana/metabolismo; Pericitos/metabolismo; Permeabilidad; Células THP-1; Factor de Necrosis Tumoral alfa/farmacología

Palabras clave

bloodbrain barrier; central nervous system disease; drug development; immortalized cell; in vitro model; spheroid

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Barrera Hematoencefálica / Esferoides Celulares Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Biol Pharm Bull Asunto de la revista: BIOQUIMICA / FARMACOLOGIA Año: 2021 Tipo del documento: Article Pais de publicación: Japón

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