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Multiscale Co-reconstruction of Lung Architectures and Inhalable Materials Spatial Distribution.
Sun, Xian; Zhang, Xiaochuan; Ren, Xiaohong; Sun, Hongyu; Wu, Li; Wang, Caifen; Ye, Xiaohui; York, Peter; Gao, Zhaobing; Jiang, Hualiang; Zhang, Jiwen; Yin, Xianzhen.
Afiliación
  • Sun X; Center for MOST and Image Fusion Analysis Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai 201210 China.
  • Zhang X; Center for Drug Delivery Systems Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai 201210 China.
  • Ren X; University of Chinese Academy of Sciences Beijing 100049 China.
  • Sun H; School of Pharmacy East China University of Science and Technology Shanghai 200237 China.
  • Wu L; CAS Key Laboratory of Receptor Research Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai 201203 China.
  • Wang C; Center for Drug Delivery Systems Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai 201210 China.
  • Ye X; Center for Drug Delivery Systems Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai 201210 China.
  • York P; Center for Drug Delivery Systems Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai 201210 China.
  • Gao Z; Center for Drug Delivery Systems Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai 201210 China.
  • Jiang H; School of Information Science and Technology University of Science and Technology of China Hefei 230027 China.
  • Zhang J; Shanghai Institute for Advanced Immunochemical Studies School of Life Science and Technology ShanghaiTech University Shanghai 200031 China.
  • Yin X; School of Pharmacy University of Bradford Bradford BD71DP UK.
Adv Sci (Weinh) ; 8(8): 2003941, 2021 04.
Article en En | MEDLINE | ID: mdl-33898181
ABSTRACT
The effective pulmonary deposition of inhaled particulate carriers loaded with drugs is a prerequisite for therapeutic effects of drug delivery via inhalation route. Revealing the sophisticated lung scaffold and intrapulmonary distribution of particles at three-dimensional (3D), in-situ, and single-particle level remains a fundamental and critical challenge for dry powder inhalation in pre-clinical research. Here, taking advantage of the micro optical sectioning tomography system, the high-precision cross-scale visualization of entire lung anatomy is obtained. Then, co-localized lung-wide datasets of both cyto-architectures and fluorescent particles are collected at full scale with the resolution down to individual particles. The precise spatial distribution pattern reveals the region-specific distribution and structure-associated deposition of the inhalable particles in lungs, which is undetected by previous methods. Overall, this research delivers comprehensive and high-resolution 3D detection of pulmonary drug delivery vectors and provides a novel strategy to evaluate materials distribution for drug delivery.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sistemas de Liberación de Medicamentos / Imagenología Tridimensional / Microtomografía por Rayos X / Inhaladores de Polvo Seco / Pulmón Límite: Animals Idioma: En Revista: Adv Sci (Weinh) Año: 2021 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sistemas de Liberación de Medicamentos / Imagenología Tridimensional / Microtomografía por Rayos X / Inhaladores de Polvo Seco / Pulmón Límite: Animals Idioma: En Revista: Adv Sci (Weinh) Año: 2021 Tipo del documento: Article