Your browser doesn't support javascript.
loading
TIMEx: tumor-immune microenvironment deconvolution web-portal for bulk transcriptomics using pan-cancer scRNA-seq signatures.
Xie, Mengyu; Lee, Kyubum; Lockhart, John H; Cukras, Scott D; Carvajal, Rodrigo; Beg, Amer A; Flores, Elsa R; Teng, Mingxiang; Chung, Christine H; Tan, Aik Choon.
Afiliación
  • Xie M; Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.
  • Lee K; Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.
  • Lockhart JH; Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.
  • Cukras SD; Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.
  • Carvajal R; Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.
  • Beg AA; Department of Immunology H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.
  • Flores ER; Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.
  • Teng M; Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.
  • Chung CH; Department of Head and Neck-Endocrine Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.
  • Tan AC; Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.
Bioinformatics ; 37(20): 3681-3683, 2021 Oct 25.
Article en En | MEDLINE | ID: mdl-33901274
ABSTRACT

SUMMARY:

The heterogeneous cell types of the tumor-immune microenvironment (TIME) play key roles in determining cancer progression, metastasis and response to treatment. We report the development of TIMEx, a novel TIME deconvolution method emphasizing on estimating infiltrating immune cells for bulk transcriptomics using pan-cancer single-cell RNA-seq signatures. We also implemented a comprehensive, user-friendly web-portal for users to evaluate TIMEx and other deconvolution methods with bulk transcriptomic profiles. AVAILABILITY AND IMPLEMENTATION TIMEx web-portal is freely accessible at http//timex.moffitt.org. SUPPLEMENTARY INFORMATION Supplementary data are available at Bioinformatics online.
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Bioinformatics Asunto de la revista: INFORMATICA MEDICA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Bioinformatics Asunto de la revista: INFORMATICA MEDICA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos