Your browser doesn't support javascript.
loading
Chemical Constituents from Chloranthus elatior and Their Inhibitory Effect on Human Dihydroorotate Dehydrogenase.
Yang, Qian; Jia, An; Liu, Xizi; Han, Shiyi; Fan, Siyang.
Afiliación
  • Yang Q; State Key Lab. of New Drug and Pharmaceutical Process, China State Institute of Pharmaceutical Industry, Shanghai, PR China.
  • Jia A; Innovation center of Traditional Chinese Medicine, Shanghai Institute of Pharmaceutical Industry, Shanghai, PR China.
  • Liu X; Medical School, Huanghe Science & Technology College, Zhengzhou, People's Republic of China.
  • Han S; State Key Lab. of New Drug and Pharmaceutical Process, China State Institute of Pharmaceutical Industry, Shanghai, PR China.
  • Fan S; Innovation center of Traditional Chinese Medicine, Shanghai Institute of Pharmaceutical Industry, Shanghai, PR China.
Planta Med ; 88(6): 455-465, 2022 May.
Article en En | MEDLINE | ID: mdl-33902131
ABSTRACT
A new sesquiterpene, chlorantholide G (1 ), a new sesquiterpene dimer, elatiolactone (2 ), and 2 new diterpenes, elatiorlabdane B (3 ) and elatiorlabdane C (4 ), together with 51 known compounds, were isolated from the aerial parts of Chloranthus elatior. The new structures including their absolute configurations were mainly established by mass spectrometric, NMR, and electronic circular dichroism experiments. All isolated compounds were tested for their anti-hDHODH activity. (4S,6R)-4-hydroxy-6-isopropyl-3-methylcyclohex-2-enone (5 ) and (4S,5R,9S,10R)-8(17),12,14-labdatrien-18-oic acid (29 ) were the most active compounds with IC50 values of 18.7 and 30.7 µM, respectively.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sesquiterpenos / Dihidroorotato Deshidrogenasa Límite: Humans Idioma: En Revista: Planta Med Año: 2022 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sesquiterpenos / Dihidroorotato Deshidrogenasa Límite: Humans Idioma: En Revista: Planta Med Año: 2022 Tipo del documento: Article