Diffuse midline glioma with H3 K27M-mutation in an 83-year-old woman.

Diffuse midline gliomas with H3 K27M mutations are a particularly aggressive form of primary glial brain tumors. They are most commonly found in children and young adults. Here, we present the unusual case of a diffuse midline glioma with H3 K27M mutation in an 83-year-old woman. To our knowledge, this is the oldest reported patient with this disease in the medical literature. We review the evolving clinical literature on this rare entity in older adults.