Intrinsically Disordered Proteins as Regulators of Transient Biological Processes and as Untapped Drug Targets.
Molecules
; 26(8)2021 Apr 07.
Article
en En
| MEDLINE
| ID: mdl-33917117
ABSTRACT
Intrinsically disordered proteins (IDPs) are critical players in the dynamic control of diverse cellular processes, and provide potential new drug targets because their dysregulation is closely related to many diseases. This review focuses on several medicinal studies that have identified low-molecular-weight inhibitors of IDPs. In addition, clinically relevant liquid-liquid phase separations-which critically involve both intermolecular interactions between IDPs and their posttranslational modification-are analyzed to understand the potential of IDPs as new drug targets.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Transducción de Señal
/
Proteínas Portadoras
/
Descubrimiento de Drogas
/
Proteínas Intrínsecamente Desordenadas
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Molecules
Asunto de la revista:
BIOLOGIA
Año:
2021
Tipo del documento:
Article
País de afiliación:
Japón