Synthesis of New Triazolopyrazine Antimalarial Compounds.

Johnson, Daniel J G; Jenkins, Ian D; Huxley, Cohan; Coster, Mark J; Lum, Kah Yean; White, Jonathan M; Avery, Vicky M; Davis, Rohan A

Johnson, Daniel J G; Jenkins, Ian D; Huxley, Cohan; Coster, Mark J; Lum, Kah Yean; White, Jonathan M; Avery, Vicky M; Davis, Rohan A.

Afiliación

Johnson DJG; Griffith Institute for Drug Discovery, School of Environment and Science, Griffith University, Brisbane, QLD 4111, Australia.
Jenkins ID; Griffith Institute for Drug Discovery, School of Environment and Science, Griffith University, Brisbane, QLD 4111, Australia.
Huxley C; Griffith Institute for Drug Discovery, School of Environment and Science, Griffith University, Brisbane, QLD 4111, Australia.
Coster MJ; Griffith Institute for Drug Discovery, School of Environment and Science, Griffith University, Brisbane, QLD 4111, Australia.
Lum KY; Griffith Institute for Drug Discovery, School of Environment and Science, Griffith University, Brisbane, QLD 4111, Australia.
White JM; NatureBank, Griffith University, Brisbane, QLD 4111, Australia.
Avery VM; School of Chemistry and Bio21 Institute, The University of Melbourne, Melbourne, VIC 3010, Australia.
Davis RA; Griffith Institute for Drug Discovery, School of Environment and Science, Griffith University, Brisbane, QLD 4111, Australia.

Molecules ; 26(9)2021 Apr 21.

Article en En | MEDLINE | ID: mdl-33919319

Asunto(s)

Antimaláricos/química; Antimaláricos/farmacología; Técnicas de Química Sintética; Pirazinas/química; Pirazinas/farmacología; Alcoholes/química; Antimaláricos/síntesis química; Cristalografía por Rayos X; Humanos; Espectroscopía de Resonancia Magnética; Modelos Moleculares; Estructura Molecular; Pruebas de Sensibilidad Parasitaria; Plasmodium falciparum/efectos de los fármacos; Pirazinas/síntesis química; Relación Estructura-Actividad

Palabras clave

Diversinate™; Open Source Malaria; X-ray; antimalarial; difluoroethylation; drug discovery; late-stage functionalization; mechanism; methylation; photoredox; radical disproportionation; synthesis; triazolopyrazine

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pirazinas / Técnicas de Química Sintética / Antimaláricos Límite: Humans Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Suiza

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