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Water-Soluble Iridium Photoredox Catalyst for the Trifluoromethylation of Biomolecule Substrates in Phosphate Buffered Saline Solvent.
Nguyen, Terrence-Thang H; O'Brien, Connor J; Tran, Minh L N; Olson, Steven H; Settineri, Nicholas S; Prusiner, Stanley B; Paras, Nick A; Conrad, Jay.
Afiliación
  • Nguyen TH; Institute for Neurodegenerative Diseases (IND), Weill Institute for Neurosciences, University of California San Francisco, San Francisco, California 94158, United States.
  • O'Brien CJ; Institute for Neurodegenerative Diseases (IND), Weill Institute for Neurosciences, University of California San Francisco, San Francisco, California 94158, United States.
  • Tran MLN; Institute for Neurodegenerative Diseases (IND), Weill Institute for Neurosciences, University of California San Francisco, San Francisco, California 94158, United States.
  • Olson SH; Institute for Neurodegenerative Diseases (IND), Weill Institute for Neurosciences, University of California San Francisco, San Francisco, California 94158, United States.
  • Settineri NS; Department of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, California 94158, United States.
  • Prusiner SB; Department of Chemistry, University of California Berkeley, Berkeley, California 94720, United States.
  • Paras NA; Institute for Neurodegenerative Diseases (IND), Weill Institute for Neurosciences, University of California San Francisco, San Francisco, California 94158, United States.
  • Conrad J; Department of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, California 94158, United States.
Org Lett ; 23(10): 3823-3827, 2021 05 21.
Article en En | MEDLINE | ID: mdl-33929208
ABSTRACT
The development of a water-soluble iridium catalyst enables the trifluoromethylation of polar small molecules and peptides in DMSO solution or aqueous media. The reaction was optimized in a microtiter plate format under ambient air, using commercial Langlois reagent as a CF3 radical source, blue LEDs for excitation, and using DPBS as solvent to provide up to 60% CF3- peptide.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fosfatos / Solventes / Mesilatos / Hidrocarburos Fluorados / Iridio Idioma: En Revista: Org Lett Asunto de la revista: BIOQUIMICA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Añadir a Mi BVS
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fosfatos / Solventes / Mesilatos / Hidrocarburos Fluorados / Iridio Idioma: En Revista: Org Lett Asunto de la revista: BIOQUIMICA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos