TNF-&#945;/NF-&#954;B signaling epigenetically represses PSD4 transcription to promote alcohol-related hepatocellular carcinoma progression.

Shi, Jia'ning; Song, Shupeng; Li, Shuangxing; Zhang, Kaili; Lan, Yinghua; Li, Yongguo

TNF-α/NF-κB signaling epigenetically represses PSD4 transcription to promote alcohol-related hepatocellular carcinoma progression.

Shi, Jia'ning; Song, Shupeng; Li, Shuangxing; Zhang, Kaili; Lan, Yinghua; Li, Yongguo.

Afiliación

Shi J; Department of Infectious Disease, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Song S; Department of Infectious Disease, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Li S; Department of Infectious Disease, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Zhang K; Department of Infectious Disease, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Lan Y; Department of Infectious Disease, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Li Y; Department of Infectious Disease, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.

Cancer Med ; 10(10): 3346-3357, 2021 05.

Article en En | MEDLINE | ID: mdl-33932127

Asunto(s)

Alcoholes/efectos adversos; Carcinoma Hepatocelular/genética; Epigénesis Genética/genética; Factores de Intercambio de Guanina Nucleótido/genética; Neoplasias Hepáticas/genética; FN-kappa B/genética; Transcripción Genética/genética; Factor de Necrosis Tumoral alfa/genética; Consumo de Bebidas Alcohólicas/genética; Animales; Cadherinas/genética; Carcinoma Hepatocelular/patología; Línea Celular Tumoral; ADN (Citosina-5-)-Metiltransferasa 1/genética; Metilación de ADN/genética; Regulación hacia Abajo/genética; Femenino; Regulación Neoplásica de la Expresión Génica/genética; Células Hep G2; Hepatocitos/patología; Humanos; Neoplasias Hepáticas/patología; Ratones; Ratones Transgénicos; Embarazo; Regiones Promotoras Genéticas/genética; Transducción de Señal/genética; Factor de Transcripción ReIA/genética

Palabras clave

EFA6B; HCC; PSD4; alcohol; p65

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Transcripción Genética / FN-kappa B / Factor de Necrosis Tumoral alfa / Carcinoma Hepatocelular / Factores de Intercambio de Guanina Nucleótido / Epigénesis Genética / Alcoholes / Neoplasias Hepáticas Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans / Pregnancy Idioma: En Revista: Cancer Med Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos

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