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Vitamin B6 deficiency hyperactivates the noradrenergic system, leading to social deficits and cognitive impairment.
Toriumi, Kazuya; Miyashita, Mitsuhiro; Suzuki, Kazuhiro; Yamasaki, Nao; Yasumura, Misako; Horiuchi, Yasue; Yoshikawa, Akane; Asakura, Mai; Usui, Noriyoshi; Itokawa, Masanari; Arai, Makoto.
Afiliación
  • Toriumi K; Project for Schizophrenia Research, Department of Psychiatry and Behavioral Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, 156-8506, Japan.
  • Miyashita M; Project for Schizophrenia Research, Department of Psychiatry and Behavioral Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, 156-8506, Japan.
  • Suzuki K; Department of Psychiatry, Tokyo Metropolitan Matsuzawa Hospital, Tokyo, 156-0057, Japan.
  • Yamasaki N; Project for Schizophrenia Research, Department of Psychiatry and Behavioral Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, 156-8506, Japan.
  • Yasumura M; Department of Psychiatry, Graduate School of Medicine, Shinshu University, Nagano, 390-8621, Japan.
  • Horiuchi Y; Kowa Company Ltd., Tokyo, 189-0022, Japan.
  • Yoshikawa A; Kowa Company Ltd., Tokyo, 189-0022, Japan.
  • Asakura M; Project for Schizophrenia Research, Department of Psychiatry and Behavioral Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, 156-8506, Japan.
  • Usui N; Project for Schizophrenia Research, Department of Psychiatry and Behavioral Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, 156-8506, Japan.
  • Itokawa M; Project for Schizophrenia Research, Department of Psychiatry and Behavioral Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, 156-8506, Japan.
  • Arai M; Center for Medical Research and Education, Graduate School of Medicine, Osaka University, Osaka, 565-0871, Japan.
Transl Psychiatry ; 11(1): 262, 2021 05 03.
Article en En | MEDLINE | ID: mdl-33941768
ABSTRACT
We have reported that a subpopulation of patients with schizophrenia have lower levels of vitamin B6 (VB6) in peripheral blood than do healthy controls. In a previous study, we found that VB6 level was inversely proportional to the patient's positive and negative symptom scale (PANSS) score for measuring symptom severity, suggesting that the loss of VB6 might contribute to the development of schizophrenia symptoms. In the present study, to clarify the relationship between VB6 deficiency and schizophrenia, we generated VB6-deficient (VB6(-)) mice through feeding with a VB6-lacking diet as a mouse model for the subpopulation of schizophrenia patients with VB6 deficiency. After feeding for 4 weeks, plasma VB6 level in VB6(-) mice decreased to 3% of that in control mice. The VB6(-) mice showed social deficits and cognitive impairment. Furthermore, the VB6(-) mice showed a marked increase in 3-methoxy-4-hydroxyphenylglycol (MHPG) in the brain, suggesting enhanced noradrenaline (NA) metabolism in VB6(-) mice. We confirmed the increased NA release in the prefrontal cortex (PFC) and the striatum (STR) of VB6(-) mice through in vivo microdialysis. Moreover, inhibiting the excessive NA release by treatment with VB6 supplementation into the brain and α2A adrenoreceptor agonist guanfacine (GFC) suppressed the increased NA metabolism and ameliorated the behavioral deficits. These findings suggest that the behavioral deficits shown in VB6(-) mice are caused by enhancement of the noradrenergic (NAergic) system.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Deficiencia de Vitamina B 6 / Disfunción Cognitiva Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Transl Psychiatry Año: 2021 Tipo del documento: Article País de afiliación: Japón

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Deficiencia de Vitamina B 6 / Disfunción Cognitiva Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Transl Psychiatry Año: 2021 Tipo del documento: Article País de afiliación: Japón
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