Diabetes increases the risk of meningioma: A systematic review and meta-analysis of observational studies.
Cancer Epidemiol
; 73: 101946, 2021 08.
Article
en En
| MEDLINE
| ID: mdl-33965653
ABSTRACT
BACKGROUND:
Increasing epidemiological evidence suggests that diabetes may be associated with meningioma risk, but the evidence supporting this association is still inconclusive. Therefore, we performed a meta-analysis of all eligible observational studies to evaluate the potential association of diabetes with meningioma risk.METHODS:
A comprehensive literature search was performed in the PubMed, Web of Science and Cochrane Library databases up to November 30, 2020. A random-effects model was applied to calculate the pooled effect size (ES) and its 95 % confidence interval (CI).RESULTS:
Eight studies were included in this study. In a random-effects pooled analysis, the results showed that DM (diabetes mellitus) increased the risk of meningioma (ES 1.17, 95 % CI 1.02-1.35, P = 0.027). In subgroup analyses, DM increased the risk of meningioma in women (ES 1.19, 95 % CI 1.02-1.40, P = 0.027) and men (ES 1.53, 95 % CI 1.25-1.88, P = 0.000). This effect was not observed in the postmenopausal group (ES 1.18, 95 % CI 0.64-2.18, P = 0.597).CONCLUSION:
Our meta-analysis showed that DM increases the risk of meningioma, but the association was only present in some subgroups. This conclusion should be further confirmed.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Diabetes Mellitus
/
Neoplasias Meníngeas
/
Meningioma
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Systematic_reviews
Límite:
Humans
Idioma:
En
Revista:
Cancer Epidemiol
Asunto de la revista:
EPIDEMIOLOGIA
/
NEOPLASIAS
Año:
2021
Tipo del documento:
Article
País de afiliación:
China