Ping Feng Qingfei mixture treats airway hyperresponsiveness: a network pharmacology and molecular docking study.
Ann Palliat Med
; 10(4): 4747-4759, 2021 Apr.
Article
en En
| MEDLINE
| ID: mdl-33966424
ABSTRACT
BACKGROUND:
As air pollution has increased in severity over recent years, fine particulate matter (PM) (<25 µm; PM2.5) has led to a greater incidence of disease, including airway hyperresponsiveness (AHR). Ping Feng Qingfei Mixture (PFQF) is effective in treating AHR caused by PM2.5. As there is a lack of knowledge regarding the mechanisms of PFQF in the treatment of AHR, we conducted a network pharmacology study to clarify this issue.METHODS:
We obtained the composition of PFQF from the traditional Chinese medicine (TCM) systems pharmacology database and its potential targets. The potential targets of AHR were obtained from the Online Mendelian Inheritance in Man and Gene Cards databases. Then psychophysiological interaction, KEGG pathway, and Gene Ontology biological process analyses were carried out for targeting PFQF in treating AHR. We further constructed a related network diagram and verified the experimental results in molecular docking.RESULTS:
We identified a total of 4 core active compounds, and through KEGG analysis obtained multiple signaling pathways, including T helper17 (Th17) cell differentiation and interleukin-17 (IL-17) signaling pathway. Our molecular docking also verified that PFQF could effectively regulate the imbalance of Th17-T regulatory (Treg) cells.CONCLUSIONS:
PFQF can effectively treat the AHR caused by PM2.5 through Th17-Treg immune balance. The combination of molecular docking and network pharmacology provides a way to elucidate the complex mechanism of action of this Chinese herbal medicine.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Medicamentos Herbarios Chinos
Tipo de estudio:
Diagnostic_studies
Idioma:
En
Revista:
Ann Palliat Med
Año:
2021
Tipo del documento:
Article
País de afiliación:
China