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Structural revision of a Wnt/ß-catenin modulator and confirmation of cannabielsoin constitution and configuration.
Monroe, Angelina Z; Gordon, William H; Wood, Jared S; Martin, Gary E; Morgan, Jeremy B; Williamson, R Thomas.
Afiliación
  • Monroe AZ; Department of Chemistry & Biochemistry, University of North Carolina Wilmington, Wilmington, North Carolina 28409, USA. williamsonr@uncw.edu.
  • Gordon WH; Department of Chemistry & Biochemistry, University of North Carolina Wilmington, Wilmington, North Carolina 28409, USA. williamsonr@uncw.edu.
  • Wood JS; Department of Chemistry & Biochemistry, University of North Carolina Wilmington, Wilmington, North Carolina 28409, USA. williamsonr@uncw.edu.
  • Martin GE; Department of Chemistry, Seton Hall University, South Orange, New Jersey 07079, USA.
  • Morgan JB; Department of Chemistry & Biochemistry, University of North Carolina Wilmington, Wilmington, North Carolina 28409, USA. williamsonr@uncw.edu.
  • Williamson RT; Department of Chemistry & Biochemistry, University of North Carolina Wilmington, Wilmington, North Carolina 28409, USA. williamsonr@uncw.edu.
Chem Commun (Camb) ; 57(46): 5658-5661, 2021 Jun 08.
Article en En | MEDLINE | ID: mdl-33972980
ABSTRACT
In this report, we revise the structure for a previously reported synthetic product proposed to be the 1R,2S-cannabidiol epoxide and reassign it as cannabielsoin using anisotropic NMR and synthetic chemistry methods. These results provide a direct link to the first known biological target and function of cannabielsoin.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cannabidiol / Proteínas Wnt / Beta Catenina Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cannabidiol / Proteínas Wnt / Beta Catenina Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos